Pharmacokinetics and absolute bioavailability of salbutamol in healthy adult volunteers
- 323 Downloads
Salbutamol was administered to sixteen healthy male volunteers intravenously and by mouth in liquid, tablet, and capsule form using a Latin-Squares design.
Pharmacokinetic parameters from intravenous data were similar to previously reported values obtained with oral administration, with a mean terminal half-life of 3.8 h and a mean clearance of 439 ml·min−1·1.73 m−2. Peak plasma concentrations of 10–20 ng·ml−1 were obtained 1–3 h following oral administration. The absolute bioavailability of each of the oral preparations was 44%.
While statistically significant differences in lag time and time to peak concentration were noted among the various oral preparations, the drug is rapidly absorbed in all three dosage forms and the observed differences are unlikely to be of clinical significance.
Key wordssalbutamol albuterol pharmacokinetics bioavailability healthy volunteers
Unable to display preview. Download preview PDF.
- 1.Walker SR, Evans ME, Richards AJ, Patterson JW (1972) The clinical pharmacology of oral and inhaled salbutamol. Clin Pharm Ther 13: 681Google Scholar
- 5.Oosterhuis B, Braat MCP, vanBoxtel CJ (1984) Analysis of β-sympathomimetics in man with high performance liquid chromatography using mode sequencing and electrochemical detection. Eur J Respir Dis 65 [Suppl 135]: 153–156Google Scholar
- 8.Loo JCK, Riegelman S (1982) Assessment of pharmacokinetic constants from postinfusion blood curves after infusion. J. Pharm Sci 59: 53–55Google Scholar
- 9.Gibaldi M, Perrier D (1982) Pharmacokinetics (2nd ed.), Marcel Dekker, New York, pp 149–155Google Scholar