European Journal of Clinical Pharmacology

, Volume 32, Issue 6, pp 631–634 | Cite as

Pharmacokinetics and absolute bioavailability of salbutamol in healthy adult volunteers

  • D. A. Goldstein
  • Y. K. Tan
  • S. J. Soldin
Short Communications


Salbutamol was administered to sixteen healthy male volunteers intravenously and by mouth in liquid, tablet, and capsule form using a Latin-Squares design.

Pharmacokinetic parameters from intravenous data were similar to previously reported values obtained with oral administration, with a mean terminal half-life of 3.8 h and a mean clearance of 439 ml·min−1·1.73 m−2. Peak plasma concentrations of 10–20 ng·ml−1 were obtained 1–3 h following oral administration. The absolute bioavailability of each of the oral preparations was 44%.

While statistically significant differences in lag time and time to peak concentration were noted among the various oral preparations, the drug is rapidly absorbed in all three dosage forms and the observed differences are unlikely to be of clinical significance.

Key words

salbutamol albuterol pharmacokinetics bioavailability healthy volunteers 


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  1. 1.
    Walker SR, Evans ME, Richards AJ, Patterson JW (1972) The clinical pharmacology of oral and inhaled salbutamol. Clin Pharm Ther 13: 681Google Scholar
  2. 2.
    Maconochie JG, Fowler P (1983) Plasma concentrations of salbutamol after an oral slow release preparation. Curr Med Res Opin 8: 634–639PubMedGoogle Scholar
  3. 3.
    Powell ML, Weisberger M, Gural R, Chung M, Patrick JE, Radwanski E, Symchowicz SS (1985) Comparative bioavailability and pharmacokinetics of three formulations of albuterol. J Pharm Sci 74: 217–219PubMedGoogle Scholar
  4. 4.
    Fairfax AJ, McNabb WR, Davies HJ, Spiro SG (1980) Slow release oral salbutamol and aminophylline in nocturnal asthma: Relation of overnight changes in lung function and plasma drug levels. Thorax 35: 526–530PubMedCrossRefGoogle Scholar
  5. 5.
    Oosterhuis B, Braat MCP, vanBoxtel CJ (1984) Analysis of β-sympathomimetics in man with high performance liquid chromatography using mode sequencing and electrochemical detection. Eur J Respir Dis 65 [Suppl 135]: 153–156Google Scholar
  6. 6.
    Tan YK, Soldin SJ (1984) Determination of salbutamol in human serum by reverse-phase liquid chromatography with amperometric detection. J Chromatogr 311: 311–317PubMedGoogle Scholar
  7. 7.
    D'Argenio DZ, Schumitzky A (1979) A program package for simulation and parameter estimation in pharmacokinetic systems. Comp Prog Biomed 9: 115–134CrossRefGoogle Scholar
  8. 8.
    Loo JCK, Riegelman S (1982) Assessment of pharmacokinetic constants from postinfusion blood curves after infusion. J. Pharm Sci 59: 53–55Google Scholar
  9. 9.
    Gibaldi M, Perrier D (1982) Pharmacokinetics (2nd ed.), Marcel Dekker, New York, pp 149–155Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • D. A. Goldstein
    • 1
  • Y. K. Tan
    • 1
  • S. J. Soldin
    • 1
  1. 1.Departments of Clinical Pharmacology and Clinical BiochemistryUniversity of Toronto and Research Institute, The Hospital for Sick ChildrenTorontoCanada

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