Medical and Biological Engineering and Computing

, Volume 23, Issue 6, pp 525–535

Mathematical model of the human renal system

  • R. J. Uttamsingh
  • M. S. Leaning
  • J. A. Bushman
  • E. R. Carson
  • L. Finkelstein
Article

DOI: 10.1007/BF02455306

Cite this article as:
Uttamsingh, R.J., Leaning, M.S., Bushman, J.A. et al. Med. Biol. Eng. Comput. (1985) 23: 525. doi:10.1007/BF02455306

Abstract

A mathematical model is presented which provides an overall description of the renal/body fluid system, comprising an interconnected set of physiologically based representations of the relevant subsystems of the human organism. The model is used to test a number of hypotheses relating to the dynamics and control of the human renal system, including dynamics of ADH clearance, glomerular tubular balance and the control of the rate of release of ADH. Results are presented establishing the validity of the model in a number of empirical tests.

Keywords

Fluid/electrolyte balance Hormonal control Kidney Mathematical model Model validation 

Copyright information

© IFMBE 1985

Authors and Affiliations

  • R. J. Uttamsingh
    • 1
  • M. S. Leaning
    • 2
    • 1
  • J. A. Bushman
    • 3
  • E. R. Carson
    • 1
  • L. Finkelstein
    • 4
  1. 1.Research Centre for Measurement & Information in MedicineThe City UniversityLondonEngland
  2. 2.Academic Department of Medical PhysicsRoyal Free Hospital School of MedicineLondonEngland
  3. 3.Research Department of AnaestheticsRoyal College of Surgeons of EnglandLondonEngland
  4. 4.Department of PhysicsThe City UniversityLondonEngland
  5. 5.C. E. LummusBloomfieldUSA

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