Comparison of three rodent neuropathic pain models
To characterize various animal models of neuropathic pain, we compared three previously developed rat models using the same behavioral testing methods. These models involve: (1) chronic constriction injury by loose ligation of the sciatic nerve (CCI); (2) tight ligation of the partial sciatic nerve (PSL); and (3) tight ligation of spinal nerves (SNL). Comparisons were made for the time course of behavioral signs representing various components of neuropathic pain as well as for the effects of surgical sympathectomy. In general, all three methods of peripheral nerve injury produced behavioral signs of both ongoing and evoked pain with similar time courses. However, there was a considerable difference in the magnitude of each pain component between models. Signs of mechanical allodynia were largest in the SNL injury and smallest in the CCI model. On the other hand, behavioral signs representing ongoing pain were much more prominent in the CCI model than in the other two. Although the behavioral signs of neuropathic pain tended to decrease after sympathectomy in all three models, the change was most evident in the SNL model. The results of the present study suggest that the three rat models tested have contrasting features, yet all are useful neuropathic pain models, possibly representing different populations of human neuropathic pain patients.
Key wordsCausalgia Hyperalgesia Mechanical allodynia Peripheral nerve injury Sympathetically maintained pain
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- Bonica JJ (1990) Causalgia and other reflex sympathetic dystrophies. In: Bonica JJ (ed) The management of pain. Lea & Febiger, Philadelphia, pp 220–243Google Scholar
- Campbell JN, Meyer RA, Raja SN (1992) Is nociceptor activation by alpha-1 adrenoreceptors the culprit in sympathetically maintained pain? APS J 1: 3–11Google Scholar
- Frost SA, Raja SN, Campbell JN, Meyer RA, Khan AA (1988) Does hyperalgesia to cooling stimuli characterize patients with sympathetically maintained pain (reflex sympathetic dystrophy)? In: Dubner R, Gebhart GF, Bond MR (eds) Proceedings of the Vth world congress on pain. Elsevier, Amsterdam, pp 151–156Google Scholar
- Kim KJ, Yoon YW, Lee BH, Chung JM (1994) Comparison of animal models for peripheral neuropathic pain. Soc. Neurosci Abstr 20: 761Google Scholar
- Lee DH, Chung K, Chung JM (1995) Importance of the location of injury on sympathetic dependency of rat models of neuropathic pain. Soc. Neurosci Abstr 21: 894Google Scholar
- Mitchell SW (1872) Injuries of nerves and their consequences. JB Lippincott, Philadelphia, pp 252–281Google Scholar
- Neil A, Attal N, Guilbaud G (199b) Effects of adrenergic depletion with guanethidine before and after the induction of a peripheral neuropathy on subsequent mechanical, heat and cold sensitivities in rats. In: Bond MR, Charlton JE, Woolf CJ (eds) Proceedings of the VIth world congress on pain. Elsevier, Amsterdam, pp 383–388Google Scholar