Increasing incidence of nosocomialChryseobacterium indologenes infections in Taiwan
To understand the clinical features, antimicrobial therapy, and epidemiology ofChryseobacterium indologenes infections, the medical records of 36 patients with nosocomialChryseobacterium indologenes infections seen over a three-year period at National Taiwan University Hospital were reviewed. The 36 isolates recovered from these patients were studied by molecular typing and determination of antimicrobial susceptibility patterns. Nine patients had underlying neoplastic diseases, seven had diabetes mellitus, five had burn wounds, and four had uremia. The clinical syndrome included ten patients with intraabdominal infections, nine with wound sepsis, six with intravascular catheter-related bacteremia, and four with ventilator-associated pneumonia. Thirteen patients had monomicrobial bacteremia, and four had polymicrobial bacteremia. Nineteen patients (53%) developed infections associated with various indwelling devices. The deaths of five patients (14%) were directly attributable to infection withChryseobacterium indologenes. All isolates recovered showed a wide range of resistance to commonly used antimicrobial agents. The random amplified polymorphic DNA (RAPD) patterns of the isolates differed from each other, indicating the absence of epidemiological relatedness among these isolates. Nosocomial infection caused by multiresistantChryseobacterium indologenes appears to be an emerging problem in Taiwan and should be studied further.
Unable to display preview. Download preview PDF.
- 2.von Graevenitz A:Acinetobacter, Alcaligenes, Moraxella, and other nonfermentative gram-negative bacteria. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH (ed): Manual of clinical microbiology. American Society for Microbiology, Washington DC, 1995, p. 520–532.Google Scholar
- 9.Siegman-Igra Y, Schwartz D, Soferman G, Konforti N:Flavobacterium group llb bacteremia: report of a case and review ofFlavobacterium infections. Microbiology and Immunology 1987, 176: 103–111.Google Scholar
- 10.Yabuuchi E, Kaneko T, Yano I, Moss CW, Miyoshi N:Sphingobacterium gen. nov.,Sphingobacterium spiritivorum comb. nov.,Sphingobacterium multivorum comb. nov.,Sphingobacterium mizutae sp. nov., andFlavobacterium indologenes sp. nov.: glucose-nonfermenting, gram-negative rods in CDC group llk-2 and llb. International Journal of Systematic Bacteriology 1983, 33: 580–598.Google Scholar
- 17.National Committee for Clinical Laboratory Standards: Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A2. NCCLS, Villanova, PA, 1993.Google Scholar
- 22.Verhasselt B, Claey G, Elaichouni A, Verschraegen G, Laureys G, Vaneechoutte M: Case of recurrentFlavimonas oryzihabitans bacteremia associated with an implanted central venous catheter (Port-A-Cath): assessment of clonality by arbitrarily primed PCR. Journal of Clinical Microbiology 1995, 33: 3047–3048.PubMedGoogle Scholar
- 25.Pollack M:Pseudomonas aeruginosa. In: Mandell GL, Bennett JE, Dolin R (ed): Mandell, Douglas and Bennett's principles and practice of infectious diseases. Churchill Livingstone, New York, 1995, p. 1980–2003.Google Scholar