Biochemical and physiological activity of new peptide inhibitors of angiotensin converting enzyme
Biophysics and Biochemistry
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Abstract
The physiological and biochemical activity of new angiotensin converting enzyme inhibitors is studiedin vitro (in microsomal fractions from the pituitary gland and corpus striatum) andin vivo. Compound PP-09, an N-carboxyalkyl derivative of enalapril, displaying high inhibiting activity towards rat serum and tissue angiotensin converting enzyme and lowering arterial pressure in spontaneously hypertensive rats, is selected.
Key Words
angiotensin converting enzyme inhibitors spontaneously hypertensive ratsPreview
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© Plenum Publishing Corporation 1997