Training of mice in the Y maze using drinking reinforcement and aversive olfactory signal: Facilitatory effect of ginsenosides
Physiology
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Abstract
The learning process is studied in mice in the Y maze using drinking as reinforcement. Fright caused in drinking mice by benzaldehyde odor at the site of reinforcement (which prolongs the latency of approach to the drinking bowl in 55% of the mice) is used as a detector of learning. Mice administered ginsenosides derived from the Korean red ginseng show significantly improved memory and learning. The percentage of animals frightened by the repellent odor increases with improved learning. Mice injected MK-801, an antagonist of NMDA receptor, more rapidly find the drinking bowl in the maze arm with repellent odor.
Key Words
maze drinking reinforcement olfaction ginseng ginsenosides NMDA receptorsPreview
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