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Bulletin of Experimental Biology and Medicine

, Volume 126, Issue 1, pp 708–711 | Cite as

Induction of immune response to plasma lipoproteins with C-reactive protein

  • P. G. Nazarov
  • I. V. Petrov
  • L. S. Kositskaya
  • L. K. Berestovaya
  • A. D. Denisenko
Microbiology and Immunology
  • 26 Downloads

Abstract

Purified C-reactive protein induces the production of autoantibodies to lipoprotein B-containing lipoproteins in animals. This is due to a C-reactive protein idiotype that permits the, interference of C-reactive protein in the idiotype-anti-idiotypical immunological reactions and stimulation of autoimmune response to lipoproteins.

Key Words

C-reactive protein low-and very low-density lipoproteins autoantibodies idiotype-anti-idiotypic regulation 

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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • P. G. Nazarov
    • 1
    • 2
  • I. V. Petrov
    • 1
    • 2
  • L. S. Kositskaya
    • 1
    • 2
  • L. K. Berestovaya
    • 1
    • 2
  • A. D. Denisenko
    • 1
    • 2
  1. 1.Department of Immunology, Institute of Experimental MedicineRussian, Academy of Medical SciencesSt. Petersburg
  2. 2.Department of Biochemistry, Institute of Experimental MedicineRussian, Academy of Medical SciencesSt. Petersburg

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