Inhibition of contractile activity of cultured rat cardiomyocytes in response to reduced oxygenation
Experimental Biology
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Abstract
Hypoxia completely abolishes the spontaneous contractile activity of cardiomyocytes. Once the original oxygenation is restored, the cells regain their functional activity, which exceeds the control level (particularly after a 2-h hypoxia). It can be assumed that the rapid restoration of cardiomyocyte functional activity is due to the preservation of a sufficiently high oxygen content and to the compensatory activation of glycolysis.
Key Words
monolayer cardiomyocyte culture hypobaric hypoxia contractile activity morphofunctional state of mitochondriaPreview
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References
- 1.S. A. Bershtein, M. I. Gurevich, and A. I. Solov'ev.Oxygen Deficiency and Vascular Tone [in Russian], Kiev (1984).Google Scholar
- 2.V. A. Volkova,Fiziol Zh. SSSR. No. 1, 122–124 (1972).Google Scholar
- 3.A. Z. Kolchinskaya, M. T. Dudarev,et al., Secondary Tissue Hypoxia [in Russian], Kiev (1983).Google Scholar
- 4.A. A. Korneev and L. D. Luk'yanova,Pat. Fiziol., No. 3, 53–56 (1987).Google Scholar
- 5.M. I. Leikina, L. L. Litinskaya, E. V. Stel'mashuk, and N. L. Ivanova, in:Fluorescence Methods in Clinical Diagnostics [in Russian], Moscow (1992), p. 21.Google Scholar
- 6.V. Lear and K. Stickney,Hypoxia [Russian translation] (1967).Google Scholar
- 7.L. D. Luk'yanova, B. S. Bayamukhanov, and A. T. Ugolev,Oxygen-Dependent Processes in the Cell and Its Functional State [in Russian], Moscow (1982).Google Scholar
- 8.Z. F. Meerson,Physiology of Adaptational Processes [in Russian], Moscow (1986), pp. 222–250.Google Scholar
- 9.L. L. Orlov, A. M. Shilov, and G. E. Roitberg,Contractile Function and Ischemia of the Myocardium [in Russian], Moscow (1987).Google Scholar
- 10.I. A. Polyakova, M. I. Leikina, D. B. Zorov, and Yu. S. Chentsov,Tsitologiya,33, No. 9, 98 (1991).Google Scholar
- 11.N. S. Stvolinskaya, Ts. I. Gerasimova, and V. F. Korovkin,Byull. Eksp. Biol. Med.,106, No. 11, 607–608 (1988).Google Scholar
- 12.D. G. Allen and C. H. Orchard,Circulat. Res.,60, No. 2, 153–168 (1987).PubMedGoogle Scholar
- 13.P. A. D'Amore and A. F. Sweet,In Vitro Cell. Dev. Biol.,23, No. 2, 123–128 (1987).PubMedGoogle Scholar
- 14.E. Millanvoge van Brussel, M. Freyss-Beguin, G. Graffation, and P. Sechat.Biochem. Pharmacol.,35, No. 1, 145–147 (1985).CrossRefGoogle Scholar
- 15.H. M. Piper, P. Schwartz, F. Hutter Zaachim,et al., Protection of Tissues against Hypoxia, Amsterdam (1982), pp. 437–442.Google Scholar
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