Bulletin of Experimental Biology and Medicine

, Volume 119, Issue 2, pp 157–159 | Cite as

Impact of 8-isoestrone analogs on estradiol binding in uterine tissue from ovariectomized rats

  • P. V. Sergeev
  • E. N. Kareva
  • E. V. Solov'eva
  • A. G. Shavva
  • Sh. N. Abusalmov
Pharmacology and Toxicology
Received:
  • 17 Downloads

Abstract

8-Isoanalogs of estrone were studied for their ability to influence estradiol binding in the cytosolic fraction of uterine tissue from ovariectomized rats and for their uterotropic activity 24 h after injection into such rats. Two groups of estrone 8-isoanalogs with opposite biological effects were identified: those increasing estradiol binding in the cytosolic fraction of uterine tissue and those decreasing this binding. Uterogenic activity was exhibited by all of the compounds tested, with the exception of compound I. No correlation was found between the uterogenic activity of the isoanalogs and hormone-receptor interactions.

Key Words

uterus estrogen receptors rats 
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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • P. V. Sergeev
    • 1
  • E. N. Kareva
    • 1
  • E. V. Solov'eva
    • 1
  • A. G. Shavva
    • 1
  • Sh. N. Abusalmov
    • 1
  1. 1.Department of Molecular Pharmacology and Radiobiology, Biomedical FacultyRussian State Medical UniversityMoscow

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