Bulletin of Experimental Biology and Medicine

, Volume 124, Issue 5, pp 1056–1058 | Cite as

Protective effect of neurotensin during vagal arrhythmias

  • O. E. Osadchii
  • V. M. Pokrovskii
  • O. G. Kompaniets
  • A. N. Kurzanov
Physiology
  • 19 Downloads

Abstract

The effects of neurotensin and its analog [d-Trp11]-neurotensin were studied on Wenckebach arrhythmia and atrioventricular dissociation provoked by vagal volley stimulation. In both cases the antiarrhythmic effect of neurotensin was observed, which was mediated by activation of cardiac β-adrenoreceptors and manifested 40–60 sec after its administration. The neurotensin analog had no cardioprotective activity, but when applied before neurotensin, it demonstrated antagonism to the protective effect of natural neurotensin.

Key Words

neurotensin Wenckebach arrhythmia atrioventricular dissociation 

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References

  1. 1.
    M. S. Kushakovskii,Cardiac Arrhythmias [in Russian], St.-Petersburg (1992).Google Scholar
  2. 2.
    E. V. Montsevichyute-Eringene,Pat. Fiziol. No. 4, 71–78 (1964).Google Scholar
  3. 3.
    O. E. Osadchii and V. M. Pokrovskii,Byull. Eksp. Biol. Med.,120, No. 7, 13–15 (1995).Google Scholar
  4. 4.
    O. E. Osadchii and V. M. Pokrovskii,Kardiologiya,35, No. 11, 57 (1995).Google Scholar
  5. 5.
    O. E. Osadchii, V. M. Pokrovskii, O. G. Kompaniets, and A. N. Kurzanov,Ross. Fiziol. Zh.,82, No. 1, 104–110 (1996).Google Scholar
  6. 6.
    N. Sperelakis,Physiology and Pathophysiology of Heart [in Russian], Moscow (1990).Google Scholar
  7. 7.
    L. A. Chahl and S. B. Walker,Life Sci.,29, No. 19, 2009–2015 (1981).PubMedCrossRefGoogle Scholar
  8. 8.
    R. Kerouas, F. Rioux, and S. St-Pierre, —Ibid.,28, No. 22, 2477–2487 (1981).CrossRefGoogle Scholar
  9. 9.
    M. Lavalee, J. De Champlain, R. A. Nadeau, and N. Yamaguchi,Can. J. Physiol. Pharmacol.,56, No. 4, 465–470 (1978).Google Scholar
  10. 10.
    R. Quirion, F. Rioux, and D. Rigoli —Ibid.,.PubMedGoogle Scholar
  11. 11.
    R. Quirion, F. Rioux, S. St-Pierre,et al., Neuropeptides,1, 253–259 (1981).CrossRefGoogle Scholar
  12. 12.
    J. E. Rivier, L. H. Lazarus, M. H. Perrin, and M. R. Brown,J. Med. Chem.,20, No. 11, 1409–1412 (1977).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • O. E. Osadchii
    • 1
  • V. M. Pokrovskii
    • 1
  • O. G. Kompaniets
    • 1
  • A. N. Kurzanov
    • 1
  1. 1.Department of Normal PhysiologyKuban Medical AcademyKrasnodar

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