Protective effect of neurotensin during vagal arrhythmias
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The effects of neurotensin and its analog [d-Trp11]-neurotensin were studied on Wenckebach arrhythmia and atrioventricular dissociation provoked by vagal volley stimulation. In both cases the antiarrhythmic effect of neurotensin was observed, which was mediated by activation of cardiac β-adrenoreceptors and manifested 40–60 sec after its administration. The neurotensin analog had no cardioprotective activity, but when applied before neurotensin, it demonstrated antagonism to the protective effect of natural neurotensin.
Key Wordsneurotensin Wenckebach arrhythmia atrioventricular dissociation
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