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Neokyotorphin and kyotorphin improve cardiovascular and cerebral resuscitation after heart arrest

  • I. B. Kharchenko
  • R. Kh. Ziganshin
  • A. V. Volkov
  • V. B. Koshelev
General Pathology and Pathological Physiology

Abstract

The effects of neokyotorphin and kyotorphin, peptides isolated from hibernates, on the rate of postresuscitational restoration and survival after a 12-min heart arrest are examined. Native peptides and peptides stabilized byd-amino acids accelerate restoration of vital functions and neurological status within several days after resuscitation. It is concluded that the use of these peptides is feasible during cardiopulmonary resuscitation.

Key Words

kyotorphin neokyotorphin heart arrest resuscitation postresuscitation period 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • I. B. Kharchenko
    • 1
    • 2
    • 3
  • R. Kh. Ziganshin
    • 1
    • 2
    • 3
  • A. V. Volkov
    • 1
    • 2
    • 3
  • V. B. Koshelev
    • 1
    • 2
    • 3
  1. 1.Laboratory of General Pathology of Terminal States, Institute of General ReanimatologyRussian Academy of Medical SciencesMoscow
  2. 2.Laboratory of PathophysiologyM. V. Lomonosov Moscow State UniversityMoscow
  3. 3.Laboratory of Peptide Chemistry, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscow

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