Effect of elementary proline-containing peptides on functional activity of anticoagulation system and primary homeostasis

  • I. P. Ashmarin
  • V. E. Pastorova
  • L. A. Lyapina
Physiology
Received:

Abstract

Elementary proline-containing peptides being added to rat platelet-rich plasma or platelet suspension in concentrations of 10−1–10−7 mg/ml elicit a considerable antiplatelet effect. Efficiency of inhibition of platelet aggregation increases in the following order: Pro-Gly>Pro-Gly-Pro>Gly-Pro-Gly-Gly. Intravenous injection of these peptides activates blood anticoagulation system in experimental animals.

Key Words

platelet aggregation elementary proline-containing peptides 
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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • I. P. Ashmarin
    • 1
  • V. E. Pastorova
    • 1
  • L. A. Lyapina
    • 1
  1. 1.Department of Human and Animal PhysiologyBiological Faculty of M. V. Lomonosov Moscow State UniversityMoscowUSSR

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