Bulletin of Experimental Biology and Medicine

, Volume 125, Issue 6, pp 576–578 | Cite as

Peripheral μ-Opiate receptors and modulation of myocardial tolerance to arrhythmogenic stimuli

  • Yu. B. Lishmanov
  • L. N. Maslov
  • A. V. Krylatov
Pharmacology and Toxicology


The peripheral μ-opiate receptor agonists DALDA and PL017 are highly effective against arrhythmias induced by adrenaline, aconitine, or CaCl2. The effect was abolished by the μ-opiate receptor antagonist CTAP. It is likely that Ca-channel block is involved in antiarrhythmic effect of DALDA.

Key Words

peripheral μ-opiate receptors arrhythmias 


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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • Yu. B. Lishmanov
    • 1
  • L. N. Maslov
    • 1
  • A. V. Krylatov
    • 1
  1. 1.Department of Experimental Cardiology, Institute of CardiologySiberian Division of the Russian Academy of Medical SciencesTomsk

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