Bulletin of Experimental Biology and Medicine

, Volume 120, Issue 1, pp 708–711 | Cite as

Study of the hemostatic properties of gaseous ozone

  • Yu. P. Kashperskii
  • A. A. Adamyan
  • V. A. Makarov
  • S. P. Glyantsev
  • V. A. Zhukov
Pharmacology and Toxicology

Abstract

The hemostatic properties of ozone were studied on models of parenchymatous (from a wound in the liver) and stem (from the stump of the tail) bleedings in rats. An air-ozone mixture at a flow rate of 1 liter/min and a concentration of 2 mg/ml was found to exert a pronounced hemostatic effect. Our findings indicate that the arrest of bleeding under the influence of ozone is due to the formation of a fibrin membrane on the surface of the flowing blood, this leading to rapid and effective hemostasis. Preliminary drying of the wound still further speeds the onset of hemostasis.

Key Words

gaseous ozone parenchymatous bleeding stem bleeding hemostasis rats 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Yu. P. Kashperskii
    • 1
    • 2
  • A. A. Adamyan
    • 1
    • 2
  • V. A. Makarov
    • 1
    • 2
  • S. P. Glyantsev
    • 1
    • 2
  • V. A. Zhukov
    • 1
    • 2
  1. 1.State Center for Surgical Dressings, Sutures, and Polymer Materials, A. V. Vishnevskii Institute of SurgeryRussian Academy of Medical SciencesMoscow
  2. 2.Department of Pathology and Pharmacology of Hemostasis, Hematology Research CenterRussian Academy of Medical SciencesMoscow

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