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Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 5, pp 1241–1244 | Cite as

Morphological and functional characteristics of human pituitary lactotrophic adenomas in cell cultures

  • I. S. Komolov
  • A. A. Bulatov
  • E. E. Makarovskaya
  • G. P. Elizarova
  • S. Yu. Serpukhovitin
  • S. Yu. Kasumova
  • E. I. Marova
Morpholocy and Pathomorphology
  • 23 Downloads

Abstract

Some features of the morphological cellular structure of prolactin secreting human pituitary adenomas and their secretion of prolactin and somatotropic hormone in primary suspension cultures were investigated. A possiblein vitro proliferation of lactotrophs was established. The inhibitory effect of somatostatin and its synthetic analog sandostatin, on prolactin secretion in prolactinomas was found to be less than in somatotropic hormone-secreting pituitary tumors.

Key Words

prolactin somatotropic hormone pituitary adenoma 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • I. S. Komolov
    • 1
  • A. A. Bulatov
    • 1
  • E. E. Makarovskaya
    • 1
  • G. P. Elizarova
    • 1
  • S. Yu. Serpukhovitin
    • 1
  • S. Yu. Kasumova
    • 1
  • E. I. Marova
    • 1
  1. 1.Research Center of EndocrinologyRussian Academy of Medical SciencesMoscow

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