Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 2, pp 856–858 | Cite as

Dose-dependent influence of buprenorphine on the phospholipid composition of cat hepatocyte plasma membranes in hemorrhagic shock

  • G. F. Leskova
  • V. I. Udovichenko
Pharmacology and Toxicology
Received:

Abstract

It is established that buprenorphine (0.3 mg/kg) induces considerable alterations in the phospholipid composition of hepatocyte plasma membranes as a result of phosphatidylserine accumulation and a considerable loss of sphingomyelin and lysophosphatidylserine. When administered in a dose of 0.03 mg/kg, buprenorphine facilitates normalization of the phosphoinositol turnover in hepatocyte plasma membranes.

Key Words

buprenorphine hemorrhagic shock hepatocyte plasma membranes phospholipids 
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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • G. F. Leskova
    • 1
  • V. I. Udovichenko
    • 1
  1. 1.Laboratory of Pathophysiology of Shock, Institute of General Pathology and Pathological PhysiologyRussian Academy of Medical SciencesMoscow

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