Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 2, pp 806–809 | Cite as

Implication of the hippocampus in the development of a pain syndrome in rats following sciatic nerve damage

  • M. L. Kukushkin
  • G. N. Kryzhanovskii
  • V. S. Smirnova
  • V. A. Zinkevich
  • V. K. Reshetnyak
Pathological Physiology and General Pathology
Received:

Abstract

Local destruction or electrostimulation of the hippocampus did not affect pain sensitivity thresholds in rats with intact sciatic nerve. In rats with transected sciatic nerve, local hippocampal damage accelerated the development of a pain syndrome considerably, while hippocampal electrostimulation delayed it so that 80% of the test rats did not appear to have been experiencing pain throughout the 45-day observation period.

Key Words

hippocampus pathological algetic system neurogenic pain syndrome 
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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • M. L. Kukushkin
    • 1
  • G. N. Kryzhanovskii
    • 1
  • V. S. Smirnova
    • 1
  • V. A. Zinkevich
    • 1
  • V. K. Reshetnyak
    • 1
  1. 1.Laboratory for Pathophysiology of Pain, Institute of General Pathology and Pathological PhysiologyRussian Academy of Medical SciencesMoscow

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