Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 1, pp 751–754 | Cite as

Fibronectin as a compensating factor in the natural cytotoxicity system in interferon-dependent immunodeficiency

  • S. B. Cheknev
  • Ya. G. Ashmanova
  • O. L. Latysheva
  • S. Zh. Toksambaeva
  • E. B. Mysyakin
  • A. Ya. Kul'berg
Microbiology and Immunology
Received:
  • 22 Downloads

Abstract

The cytotoxicity of natural killer cells (NK) against3H-uridine-labeled target cells (TC, human erythromyeloleukosis cells K-562) and the intensity of conjugate formation in the NK:TC system in the presence of γ-interferon, C-reactive protein, and human fibronectin are studiedin vitro in 14 patients with multiple sclerosis. It is shown that γ-interferon and C-reactive protein decrease the cytotoxic activity of NK with a simultaneous stimulation of conjugate formation in the NK:TC system. The correlation between the studied parameters becomes weaker. Human fibronectin induces collateral changes in the activity of NK and in the number of effector:target conjugates formed in the natural cytotoxicity reaction.

Key Words

fibronectin natural cytotoxicity compensation 
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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • S. B. Cheknev
    • 1
    • 2
  • Ya. G. Ashmanova
    • 1
    • 2
  • O. L. Latysheva
    • 1
    • 2
  • S. Zh. Toksambaeva
    • 1
    • 2
  • E. B. Mysyakin
    • 1
    • 2
  • A. Ya. Kul'berg
    • 1
    • 2
  1. 1.Laboratory of Immunochemistry, N. F. Gamaleya Institute of Microbiology and EpidemiologyRussian Academy of Medical SciencesMoscow
  2. 2.Group of Immunopharmacology, Laboratory of Natural Immunity, N. F. Gamaleya Insitute of Microbiology and EpidemiologyRussian Academy of Medical SciencesMoscow

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