Journal of Neurology

, Volume 243, Issue 2, pp 137–142

Neurological complications of liver transplantation

  • Maria Guarino
  • Andrea Stracciari
  • Paolo Pazzaglia
  • Roberto Sterzi
  • Ignazio Santilli
  • Franca Donato
  • Roberto D’Alessandro
Original Communication


We examined 199 consecutive patients who underwent 220 liver transplantations, to define the type, frequency and aetiology of posttransplant neurological complications and their prognostic value. We found neurological complications in 63 patients (32%), mostly involving the central nervous system. The most frequent complications were mental status changes ranging from delirium to coma and seizures. The aetiology was multifactorial, cyclosporin A neurotoxicity being the main cause. Patients with neurological complications had a higher mortality rate than those without. In our series, neurological complications represented a major medical problem with increased morbidity and mortality.

Key words

Liver transplantation Mental status Seizures Peripheral neuropathy 


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Maria Guarino
    • 1
  • Andrea Stracciari
    • 1
  • Paolo Pazzaglia
    • 1
  • Roberto Sterzi
    • 2
  • Ignazio Santilli
    • 2
  • Franca Donato
    • 2
  • Roberto D’Alessandro
    • 1
  1. 1.Servizio di NeurologiaPoliclinico S. Orsola-MalpighiBolognaItaly
  2. 2.Divisione di NeurologiaOspedale NiguardaMilanItaly

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