Effect of salicylates on the toxicity of GABA-lytics in mice
Biophysics and Biochemistry
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Abstract
Preliminary injection of aspirin and salicylic acid increases the toxicity of picrotoxin, but not of bicuculline. Aspirin inhibits binding of3H-diazepam and N-methyl-3H-methylphenazepam with membranes from the brain of intact mice. In view of the fact that salicylates reduce the content and sorption capacity of serum albumin, this protein can be assumed to be involved in the detoxication of picrotoxin.
Key Words
GABA-lytics salicylates toxicity receptors Serum albuminPreview
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References
- 1.A. I. Golovko, G. A. Sofronov, and T. V. Klyuntina,Byull. Eksp. Biol. Med.,115, No 4, 382–383 (1993).CrossRefGoogle Scholar
- 2.A. I. Golovko, G. A. Sofronov, T. V. Nikolaeva, and T. V. Klyuntina,,114, No 9, 290–291 (1992).Google Scholar
- 3.A. I. Golovko, G. A. Sofronov, T. V. Nikolaeva,et al.,, No 10, 396–397 (1993).Google Scholar
- 4.A. I. Luik and V. D. Luk'yanchuk,Serum Albumin and Biological Transport of Toxins [in Russian], Moscow (1984).Google Scholar
- 5.M. A. Yasinovskii, A. F. Leshchinskii, Z. S. Barlagan, and N. A. Ostapchuk,Salicylates: Current Insights into Pharmacodynamics and Clinical Use [in Russian], Moscow (1976).Google Scholar
- 6.J. E. Casida, C. J. Palmer, and L. M. Cole,Molec. Pharmacol.,28, No 3, 246–253 (1985).Google Scholar
- 7.M. Farrant and R. A. Webster,Drugs as Tools in Neurotransmitter Research. New York (1989), pp. 161–201.Google Scholar
- 8.L. J. Lowrence and J. E. Casida,Life Sci.,35, No 2, 171–178 (1984).CrossRefGoogle Scholar
- 9.T. E. Sokrab, H. Kalimo, and B. B. Johansson,Brain Res.,489, No 2, 231–236 (1989).PubMedCrossRefGoogle Scholar
- 10.Y. Teraki and S. Maemura,Europ. J. Pharmacol.,183, No 6, 2453 (1990).CrossRefGoogle Scholar
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