Synthesis of an analogue of the lipoglycopeptide membrane intermediate I of peptidoglycan biosynthesis
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- Auger, G., Crouvoisier, M., Caroff, M. et al. Lett Pept Sci (1997) 4: 371. doi:10.1007/BF02442902
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α-Dihydroheptaprenyl-pyrophosphoryl-N-acetylmuramoyl-L-Ala-γ-D-Glu-meso-diaminopimeloyl(N∈-dansyl)-D-Ala-D-Ala (1), an analogue of lipid I of peptidoglycan biosynthesis, was synthesized from natural UDP-N-acetylmuramoyl-pentapeptide in three steps. Compound1 was shown to be a substrate for the MurG transferase fromEscherichia coli, even in the absence of membranes. When membranes were present, dansylated peptidoglycan was also formed.