Laser Doppler measurement of blood velocity in microvessels

  • T. Cochrane
  • J. C. Earnshaw
  • A. H. G. Love


The application of laser Doppler velocimetry to the measurement of blood flow in narrow vessels is considered. Particular attention is paid to the effect of the finite laser probe volume (velocity gradient averaging). Successful in vitro results are reported but it is concluded that in vivo applications are likely to be confined to certain accessible vascular systems.


Velocity Profile Biological Engineer Autocorrelation Function Laser Doppler Velocimetry Velocity Spectrum 
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  1. Atherton, A. andBorn, G. V. R. (1973) Relationship between the velocity of rolling granulocytes and that of the blood flow in venules.J. Physiol.,233, 157–165.Google Scholar
  2. Born, G. V. R., Melling, A. andWhitelaw, J. H. (1978) Laser Doppler microscope for blood velocity measurements. Biorheology,15, 163–172.Google Scholar
  3. Charm, S. E. andKurland, G. S. (1974) Blood flow and microcirculation, New York, Wiley.Google Scholar
  4. Cochrane, T. (1977) Photon correlation studies of laminar fluid flow in narrow vessels: with application to blood flow, Ph.D. thesis, The Queen's University, Belfast.Google Scholar
  5. Cochrane, T. andEarnshaw, J. C. (1978a) Practical laser Doppler microscopes,J. Phys. E: Sci. Instrum 11, 196–198.CrossRefGoogle Scholar
  6. Cochrane, T. andEarnshaw, J. C. (1978b) Laser Doppler measurements in spatially restricted flows.J. Phys. D: Appl. Phys.,11, 1509–1516.CrossRefGoogle Scholar
  7. Cummins, H. Z. andPike, E. R. (Eds.) (1977)Photon correlation spectroscopy and velocimetry, Plenum, New York.Google Scholar
  8. Davies, A. R., Cochrane, T. andAl-Faour, O. M. (1980) The numerical inversion of truncated autocorrelation functions.Optica Acta,27, 107–118.Google Scholar
  9. Dintenfass, L. (1976) Rheology of blood in diagnostic and preventive medicine, Butterworths, London.Google Scholar
  10. Durst, F. andWhitelaw, J. H. (1971) Optimization of optical anemometers, Proceedings of the Royal Society, London, A324, 157–181.CrossRefGoogle Scholar
  11. Durst, F., Melling, A. andWhitelaw, J. H. (1976)Principles and practice of laser Doppler anemometry, Academic Press, London.Google Scholar
  12. Einav, S., Berman, H. J., Fuhro, R. L., Di Giovanni, P. R., Fridman, J. D. andFine, S. (1975a) Measurement of blood flowin vivo by laser Doppler anemometry through a microscope.Biorheology,12, 203–205.Google Scholar
  13. Einav, S., Berman, H. J., Fuhro, R. L., Di Giovanni, P. R., Fine, S. andFridman, J. D. (1975b) Measurement of velocity profiles of red blood cells in the microcirculation by laser Doppler anemometry (LDA),Biorheology,12, 207–210.Google Scholar
  14. Feke, G. T. andRiva, C. E. (1978) Laser Doppler measurements of blood velocity in human retinal vessles.J. Opt. Soc. Am. 68, 526–531.Google Scholar
  15. Goldsmith, H. L. andMarlow, J. (1972) Flow behaviour of erythyrocytes. I rotation and deformation in dilute suspensions. Proceedings of the Royal Society, B182, 351–384.CrossRefGoogle Scholar
  16. Goldsmith, H. L. andMarlow, J. (1979) Flow behaviour of erythyrocytes. II particle motions in concentrated suspensions of ghost cells.J. Coll. & Int. Science,71, 383–407.CrossRefGoogle Scholar
  17. Kreid, D. K. andGoldstein, R. J. (1971) Measurement of velocity profiles in simulated blood by the laser Doppler technique. ISA Symposium on Flow—Its measurement and Control in Science and Industry, paper 4-2-95, Pittsburgh.Google Scholar
  18. Mishina, H., Koyama, T. andAsakura, T. (1975) Velocity measurements of blood flow in the capillary and vein using a laser Doppler microscope.Appl. Optics 14, 2326–7.CrossRefGoogle Scholar
  19. Tanaka, T. andBenedek, G. B. (1975) Measurement of the velocity of blood flow (in vivo) using a fiber optic catheter and optical mixing spectroscopy.Applied Optics,14, 189–196.Google Scholar
  20. Yoganathan, A. P., Reamer, H. H., Corcoran, W. H. andHarrison, E. C. (1979) Laser Doppler anemometer to study velocity fields in the vicinity of prosthetic heart valves.Med. & Biol. Eng. & Comput.,17, 38–44.Google Scholar

Copyright information

© IFMBE 1981

Authors and Affiliations

  • T. Cochrane
    • 1
    • 2
  • J. C. Earnshaw
    • 1
    • 2
    • 3
  • A. H. G. Love
    • 1
    • 2
  1. 1.Department of Physics, Medical Physics and Biophysical GroupThe Queen's UniversityBelfastNorthern lreland
  2. 2.Department of MedicineRoyal Victoria Hospital and The Queen's UniversityBelfastNorthern lreland
  3. 3.Department of Medical Electronics and ComputingSt. Bartholomew's HospitalLondonEngland

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