International Journal of Anthropology

, Volume 11, Issue 1, pp 57–79 | Cite as

Anthropological study on spina bifida in the Community of Madrid

  • E. Gutiérrez
  • R. Grande
  • C. Susanne


The incidence of spina bifida in the Community of Madrid (Spain) has been assessed during an eleven-year period, since 1970 to 1980: 0.37 per 1,000 newborns over a total of 272,332 newborns, dead and alive, of simple births. The sex ratio at birth was 94. Maternal variables have been studied (maternal age, menarche, parity, etc.), obstetric variables (number of abortions, medication during pregnancy, etc.) and also neonatal variables (weight, gestational age, state at birth, etc.). Seasonal variations were observed.

Key words

Spina bifida biological traits seasonality Spain 


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  1. AVERY, G.B. 1990. Neonatología. Fisiología y manejo del recién nacido. Ed. Medica Panamericana. Buenos Aires.Google Scholar
  2. BALE, P.M. 1984. Sacrococcygeal developmental abnormalities and tumors in children.Perspect. Pediatr. Pathol. 1:9–56.Google Scholar
  3. BARAIBAR, R., SIMON, M.A., MEDAGUA, R.M., KRAVEL, J., MOLINA, V. and CARRERA, J.M. 1982. Valoración de la historia perinatal y de la conducta obstétrica en los embarazos de neonatos on malformaciones del Sistema Nerviso Central.An. Esp. Pediatr. 16:290–294.Google Scholar
  4. BORMAN, B. and CRYER, C. 1993. The prevalence of anencephalus and spina bifida in New Zealand.J. Paediatr. Child. Health. 29:282–288.Google Scholar
  5. BORMAN, G.B., SMITH, A.H. and HOWARD, J.K. 1986. Risk factors in the prevalence on anencephalus and spina bifida in New Zealand.Teratology 33:221–230.CrossRefGoogle Scholar
  6. BOWER, C. and STANLEY, F.J. 1992. Pericenteptional vitamine supplementation and neura tube deffects; evidence from a case-control study in Wenster Australia and a review of recents publications.J. epidemiology and Community Health 46:157–161.Google Scholar
  7. CAMPBELL, L.R., DAYTON, D.H. and SOHAL, G.S. 1986. Neural tube defects: a review cohuman and animal studies on the aetiology of neural tube defects.Teratology, 34:171–187.CrossRefGoogle Scholar
  8. CARRERA, J.M., ALEGRE, M., NAVARRETE, L., SAVATER, L. and SOLE, M.T. 1987.Diagnóstico prenatal. Ed. Salvat. Barcelona.Google Scholar
  9. CARTER, C.O. and EVANS, K. 1973. Spinal Bifida and Anencephalus in Greater London.Diarnal of Medical Genetics, 10:209–234.CrossRefGoogle Scholar
  10. CARTER, C.O., DAVID, D.A. and LAURENCE, K.M., 1968. A family study of major central nervous system malformations in South Wales.J. of Medical Genetics, 5:81–106.Google Scholar
  11. CASTILLA, E.E., ORIOLI, I.M., LUGARINHO, R., DUTRA, G.P., LOPEZ-CAMELO, J.S., CAMBNA, H.E., SPAGNULO, A. and MASTROIACUVE, P. 1990. Mounthly and seasonal variation in therequency of congenital anomalias.International Journal of Epidemiology, 19:399–404.Google Scholar
  12. CHRISTODORESCU, D., ALUPULUI, R., CRISTESCU, F., SANDU, D. and URSE, M. 1981. Incidence of neural tube malformations in Bucharest over 1977–1980.Neurol. Psychiatr. 19:235–246.Google Scholar
  13. COLLMANN, R.D. and STOLLER, A. 1962. Epidemology of congenital anomalies of the central nervous system with special reference to patterns in the State of Victoria, Australia.J. Ment. Defic. Res., 6:22–37.Google Scholar
  14. COPP, A. and BROOK, F.A. 1989. Does lumbosacral spina bifida arise by failure of neural folding or by defective canalisation?.J. Med. Genet., 26:160–166.Google Scholar
  15. COPP, A., BROOK, F.A., ESTIBEIRO, P., SHUM, A.S.W. and COCKROFT, D.L. 1990. The embryonic development of mammalian neural tube defects.Progr. Neurobiol., 35:363–403.CrossRefGoogle Scholar
  16. CZEIZEL, A. and REVERSZ, D. 1970. Major malformations of the nervous system in Hungary.Br. J. Rev. Soc. med., 24:205–222.Google Scholar
  17. DANKS, M.A. and HALLYDAY, J.L. 1983. Incidencia of neural tube defects in Victoria, Australia.The Lancet, 1:65.CrossRefGoogle Scholar
  18. ELWOOD, J.M., and ELWOOD, J.H. 1980.Epidemiology of anencephalus and spina bifida. Oxford University Press. Oxford.Google Scholar
  19. ELWOOD, J.M., LITTLE, J. and ELWOOD, J.H. 1992.Epidemiology and control of neural tube defects. Oxford University Press. Oxford.Google Scholar
  20. EVANS, D.R. 1979. Neural-tube defects: importance of a history of abortion in aetiology.British Medical Journal, 1:975–976.Google Scholar
  21. EVERETT, C., ASHURST, H. and CHALMERS, I. 1987. Reparted management of threatened miscarriage by general practitioners in Wessex.Br. Med. J. 295:583–586.Google Scholar
  22. GARCIA-MORO, C. and HERNANDEZ, M. 1986. Variación secular del periodo y del ciclo menstrual en mujeres españolas.Acta Ginecológica., XLIII:609–116.Google Scholar
  23. GARDNER, W.J. 1980. Hypothesis: overdistention of the neural tube may case anomalies of non-neural organs.Teratology, 22:229–238.CrossRefGoogle Scholar
  24. GAYLE, C., WINDHAM, L. and EDMONDS, D.E. 1982. Tendencia actual de la incidencia de los defectos del tubo neural.Pediatrics, 174–178.Google Scholar
  25. GOODMAN, R.M. and GORLIN, R.J. 1986.Malformaciones en el lactante y en el niño. Salvat Editores. Barcelona.Google Scholar
  26. GRANDE, R.M. 1974. Causas de la variabilidad en el desarrollo ponderal de los recién nacidos españoles. Tesis doctoral. Universidad Complutense de Madrid.Google Scholar
  27. GRANDE, R.M. and ARGÜELLES, F. 1978. Variación estacional de la proporción de sexos en una muestra de fetos menores de 28 semanas de gestación, 473–484. I Simposio de Antropología Biológica de España. Ed. S.E.A.B.-Madrid.Google Scholar
  28. GRANROTH, G., HAKAMA, M. and SAXÓN, L. 1977. Defects of the central nervous system in Finland: I. Birth order, outcome of previous pregnanceies and family history.Teratology 17:213–222.CrossRefGoogle Scholar
  29. GRUPO DE TRABAJO D.U.P. ESPAÑA. 1991a. Estudio multicéntrico sobre el uso de medicamentos durante el embarazo en España (II). Los fármacos utilizados durante la gestación.Medicina Clínica, 96:11–15.Google Scholar
  30. GRUPO DE TRABAJO D.U.P. ESPAÑA. 1991b. Estudio multicéntrico sobre el uso de medicamentos durante el embarazo en España (III). Los fármacos utilizados durante el primer trimestre de la gestación.Medicina Clínica, 96:52–57.Google Scholar
  31. HALL, J.G., FRIEDMAN, J.M., KENNA, B.A., POPKIN, J., JAWANDA, M. and ARNOLD, W., 1988. Clinical, Genetic and Epidemiological Factors in Neural Tubs Defects.Am. J. Hum. Genet., 43:827–837.Google Scholar
  32. HATHCOCK, J.N., HATTAN, D.G., JENKINS, M.Y., MCDONALD, J.T., SUNDARESAN, P.R. and WILKENING, V.L. 1990. Evaluation of vitamin A toxicity.Am. J. Clin. Nutr., 52:183202.Google Scholar
  33. HUNT, G.M., 1983. A study of deaths and handicep in a consecutive series of spina bifida treated inselectively from birth.Z. Kinderchir, 38:100–102.Google Scholar
  34. ICBDMS (International Clearinghouse for Birth Defects Monitoring Systems) 1985. Annual Report 1984. V.R. Ward. Government printer, Wellington, New Zealand.Google Scholar
  35. ICBDMS (International Clearinghouse for Birth Defects Monitoring Systems) 1991. Congenital Malformations Worldwide Elsevier Science Publishers B.V.Google Scholar
  36. IMAIZUMI Y. 1974. Statistical Analysis on Anencephaly, Spina Bifida and Congenital Hydrocephaly in Japan.Jap. J. Human. Genet. 19:115–135.Google Scholar
  37. JANERICH, D.T. 1975. Female excess in anencephaly and spina bifida: possible gestational influences.Am. J. Epidemiol., 101:70–76.Google Scholar
  38. KHOURY, M.J., ERICKSON, D.J. and JAMES, L.M. 1982a. Etiologic heterogeneity of neural tube defects: I. Clues from epidemiology.Am. J. of Epidemiology 115:538–548.Google Scholar
  39. KHOURY, M.J., ERICKSON, D.J. and JAMES, L.M. 1982b. Etiologic heterogeneity of neural tube defects: I. Clues from family studies.Am. J. of Hum. Genet., 34: 980–987.Google Scholar
  40. LAMMER, E.J. 1988. A phenocopy of the retinoic acid-embriopathy following maternal use of etretinate that ended one year before conception.Teratology, 37:472.CrossRefGoogle Scholar
  41. LAMMER, E.J., CHEN, D.T., HOAR, R.M., AGNISH, N.D., BENKE, P.J. and BRAUJ, J.T. 1985. Retinoic acid embryopathy. N. Engl. J. Med., 313:837–841.CrossRefGoogle Scholar
  42. LAMMER, E.J., HAYES, A.M., SCHUNIOR, A. and HOLMES, L.B. 1987. Risk for major malformations among human fetuses exposed to isotretinoin (13-cis-retinoic acid). Teratology, 35: 68A.CrossRefGoogle Scholar
  43. LAURENCE, K.M., CARTER, C.O. and DAVID, P.A. 1968. Major Central Nervous System malformations in South Wales. II. Pregnancy factors, seasonal variation and social class effects.Br. J. Prev. Soc. Med., 22:212–222.Google Scholar
  44. LAURENCE, K.M., JAMES, N., MILLER, M. and CAMPBELL, H. 1980. Increased risk of recurrence of pregnancies comlicated by fetal neural tube defects in mothers receiving poor diets and posible benefict of dietary counselling.Br. Med. J., 31:1592–1594.CrossRefGoogle Scholar
  45. LEMIRE, R.J. 1988. Neural tube defects.J. Am. Med. Assoc., 259:558–62.CrossRefGoogle Scholar
  46. MACMAHON, B., PUGH, T.F. and INGALLS, T.H. 1953. Anencephalus, spina bifida and hydrocephalus. Incidence related to sex, race and seasonal of birth and incidence in siblings.Br. J. Prev. Soc. Med., 7:211–219.Google Scholar
  47. MARTINEZ-FRIAS, M.L. 1989. Medicamentos y teratogenia: revisión bibliográfica y situación en España. Ed. Salvat. Barcelona.Google Scholar
  48. MARTINEZ-FRIAS, M.L., DARRALO, J.A. and SALVADOR, J. 1986. Sex ratios in neural tube defects.The Lancet 11:871–872.CrossRefGoogle Scholar
  49. MARTINEZ-FRIAS, M.L., SALVADOR, J., TARAMONA, A., ALONSO, M.D. and PRIETO, L., 1984. Estudio epidemiológico descriptivo de las anomalías congénitas del Sistema Nervioso Central en España.An. Esp. Pediatr. 21:810–821.Google Scholar
  50. MARTINEZ-FRIAS, M.L. and SALVADOR, J. 1990. Epidemiological aspects of prenatal exposure to high doses of vitamin A in Spain.Eur. J. Epidemial, 6:118–123.CrossRefGoogle Scholar
  51. MCKEOWN, T. and RECORD, R.G. 1951. Seasonal incidence of congenital malformations of the central nervous system. The Lancet, 1: 192–196.CrossRefGoogle Scholar
  52. MEMORIAS DE ACTIVIDADES (1965–1970) DE LA MATERNIDAD “LA PAZ”. 1972.Monografías Médicas de la Seguridad Social. Ministerio de Trabajo. Instituto Nacional de Previsión. Madrid.Google Scholar
  53. MEMORIAS DE ACTIVIDADES (1971–1975) DE LA MATERNIDAD “LA PAZ”. 1978.Monografías Médicas de la Seguridad Social. Ministerio de Trabajo. Instituto Nacional de Previsión. Madrid.Google Scholar
  54. MEMORIAS DE ACTIVIDADES (1976–1980) DE LA MATERNIDAD “LA PAZ”. 1984.Monografías Médicas de la Seguridad Social. Ministerio de Trabajo. Instituto Nacional de Previsión. Madrid.Google Scholar
  55. MESA, M.S., 1973. Estudio del polimoifismo genético de los sistemas Rh y Kell en la comarca natural de La Mancha.Trabajos de Antropología. C.S.I.C., 16–4:245–251.Google Scholar
  56. MILLS, J.L., RHOADS, S.G., SIMPSON, J.L., CNNINGHAM, G.C., LONLEY, M.R., LASSMAN, M.R., WALDEN, M.E., DEPP, R. and HFFMAN, H.J. 1989. The absence of a relation between the periconceptional use of vitamins and neural-tube deffects.New England Journal of Medicine, 321:430–435.CrossRefGoogle Scholar
  57. MRC (Medical Research Council). Vitamin Study Research Group. 1991. Prevention of neural tube defects: results of the Medical Researchs Council vitamin study. The Lancet, 338:131–137.CrossRefGoogle Scholar
  58. NAGGAN, L. 1971. Anencephaly and spina bifida in Israel.Pediatrics 47:577–586.Google Scholar
  59. OPITZ, J.M. 1982. The developmental field concept in clinical genetics.J. Pediatr., 101:805–809.CrossRefGoogle Scholar
  60. POLEDNAK, A., 1986. Birth defects in Blacks and Whites in relation to prenatal development: A review and hypothesis.Human Biology, 58:317–335.Google Scholar
  61. PRADO, C. 1990. Report on the natural interruption of pregnancy related to menarche in the population of Madrid.Am. J. of Human Biology 2:691–694.CrossRefGoogle Scholar
  62. RUIZ DE TEMIÑO BRAVO, M., GARCIA, J., RIHUTE HERAS, M.A., ELIAS POLLINA, J. and ESTEBAN IBARZ, J.A. 1987. Análisis de la mortalidad en el mielomeningocele. An. Esp. Pediatr., 26, 4: 271–273.Google Scholar
  63. SALVADOR, J., JIMENO, I. and MARTINEZ-FRIAS, M.L. 1983. Incidence of neural tube defective live births in Spain register.Teratology, 28:45A.CrossRefGoogle Scholar
  64. SANDAHL, B. 1977. Seasonal incidence of some congenital malformations in the central nervous system in Sweeden.Acta Paediatr. Scan., 66:65–72.Google Scholar
  65. SELLER, M.J. 1987. Neural tube defects and sex ratios.American J. of. Medical Genetics, 26:699–707.CrossRefGoogle Scholar
  66. SELLER, M.J. and NEVIN, N.C. 1984. Periconceptional vitamin supplementation and the prevention of neural tube defects in south-east England and Northern Ireland.Journal of Medical Genetics, 21:325–330.Google Scholar
  67. SEVER, L.E. 1982. An epidemiologic study of neural tube defects in Los Angeles County. II. Etiologic factors in area with low prevalence at birth.Teratology, 25:323–334.CrossRefGoogle Scholar
  68. SHERRY, C.J. and BAKER, D. 1982. Spina bifida and maternal Rh phenotype.Experientia, 38: 323–324.CrossRefGoogle Scholar
  69. SIEGEL, S. 1980.Estadistica no paramétrica. Ed. Trillas. México.Google Scholar
  70. SIMPSON, J.L., MILS, J., RHOADS, G.G., CONNINGHAM, G.C., CONLEY, M. R. and HOFFMAN, H.L. 1991. Genetic Heterogeneity in Neural Tube defects.Ann. Génét. 34:279–286.Google Scholar
  71. SMILKSTEIN, G. 1962. A ten year study of anencephaly.Calif. Med., 96:350–353.Google Scholar
  72. SMITHELLS, R.W. and CHINN, E.R. 1965. Spina bifida in liverpool.Dev. Med. Child Neurol., 6: 231–240.CrossRefGoogle Scholar
  73. SLATTERY, M.L. and JANERICH, D.T. 1991. The epidemiology of neural tube deffects: a review of dietary intake and related factors as etiologic agents. Am J. Epidemiology 133: 526–540.Google Scholar
  74. STANGE, L., CARLSTOM, K. and ERICKSSON, M. 1978. Hipervitaminosis in early human pregnancy and malformations of the central nervous systems.Act. Obstet. Gynecol. Scand., 57:289–291.CrossRefGoogle Scholar
  75. STOTT, C., DOTT, B., RHOTH, M.P. and ALAMBIK, Y. 1988. Aspects étioliqìques et épidémiologiques des anomalies du tube neural.Arch. Fr. Pediatr., 45:617–622.Google Scholar
  76. VALLS, A. 1975. Seroantropologia de la población española.Revista de la Universidad Complutense, 24:111–139.Google Scholar
  77. VANRELL, J.A., IGLESIAS, X. and CABERO, LL. 1993.Manual de obstetricia y ginecologia para pregraduados. Ed. Ediciones Científicas y Técnicas, Masson-Salvat. Barcelona.Google Scholar
  78. WARKANY, J. 1971.Congenital malformations. Year Book Publishers. Chicago.Google Scholar
  79. WEHRUNG, D.A. and HAY, S., 1970. A study of seasonal incidence of congenital malformations in the United States.Br. J. Prev. Soc. Med., 24:24–32.Google Scholar
  80. XERCAVINS, J. and PAYA, A. 1993. Presentacion podálica pelviana o de nalgas, 311–320. En:Manual de Obstetricia y Ginecologia para pregraduados. Ed. Salvat.Google Scholar

Copyright information

© International Institute for the Study of Man 1996

Authors and Affiliations

  • E. Gutiérrez
    • 1
  • R. Grande
    • 1
  • C. Susanne
    • 2
  1. 1.Dept. Biología animalUniversity of Alcalá de HenaresAlcalá de HenaresSpain
  2. 2.Free UniversityBrusselsBelgium

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