AGE

, Volume 1, Issue 2, pp 60–67 | Cite as

Review: A comparative analysis of studies of enzyme changes with age, with comments on possible sources of error

  • Heinrich F. Klefenz
  • Bert M. Zuckerman
Article

Abstract

Studies on enzyme changes during aging from rodents, nematodes and tissue culture cells have been reviewed. In the rodent and tissue culture studies, conflicting results on aging of specific enzymes have been reported from several laboratories. These works have been analyzed, with the aim of stressing the different findings and analyzing possible reasons for the discrepancies. With regard to the nematode studies, the authors suggest that the examination of the concept of general failure of protein synthesis mechanisms as a basic cause of cellular senescence requires more rigorous methods than have been utilized in previous studies.

Keywords

Culture Cell Tissue Culture Protein Synthesis Comparative Analysis Culture Study 
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Copyright information

© American Aging Association, Inc. 1978

Authors and Affiliations

  • Heinrich F. Klefenz
    • 1
  • Bert M. Zuckerman
    • 2
  1. 1.Institut für Biochemie I die Universität HeidelbergHeidelbergGermany
  2. 2.Laboratory of Experimental BiologyUniversity of MassachusettsEast Wareham

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