Bulletin of Experimental Biology and Medicine

, Volume 129, Issue 4, pp 367–369 | Cite as

Effects of antitumor drugs on offspring

  • E. D. Gol'dberg
  • T. G. Borovskaya
  • M. E. Poluektova
Pharmacology and Toxicology


The offspring of Wistar rats obtained from parents, one of which received platinum-containing drug Platidiam (cisplatin) or anthracycline antibiotics Doxorubicin and Farmorubicin was characterized by low viability (embryonic death increased 4–30-fold compared to control) and congenital malformations. The fetuses displayed pathology in internal organs and low ossification rates. Newborn rats are characterized by low survival rate and retarded physical development.

Key Words

Platidiam Doxorubicin Farmorubicin offspring 


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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • E. D. Gol'dberg
    • 1
  • T. G. Borovskaya
    • 1
  • M. E. Poluektova
    • 1
  1. 1.Institute of Pharmacology, Tomsk Research CenterSiberian Division of the Russian Academy of Medical SciencesUSSR

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