Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 129, Issue 4, pp 367–369 | Cite as

Effects of antitumor drugs on offspring

  • E. D. Gol'dberg
  • T. G. Borovskaya
  • M. E. Poluektova
Pharmacology and Toxicology

Abstract

The offspring of Wistar rats obtained from parents, one of which received platinum-containing drug Platidiam (cisplatin) or anthracycline antibiotics Doxorubicin and Farmorubicin was characterized by low viability (embryonic death increased 4–30-fold compared to control) and congenital malformations. The fetuses displayed pathology in internal organs and low ossification rates. Newborn rats are characterized by low survival rate and retarded physical development.

Key Words

Platidiam Doxorubicin Farmorubicin offspring 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    M. M. Belen'kii, in:Fundmentals of Quantitative Evaluation of Pharmacological Effects [in Russian], Leningrad (1963) pp. 81–108.Google Scholar
  2. 2.
    A. P. Dyban, V. S. Baranov, and I. M. Akimova,Arkh. Anat.,59, No. 10, 89–100 (1970).PubMedGoogle Scholar
  3. 3.
    Anticancer Chemotherapy, Ed. N. I. Perevodchikova [in Russian], Moscow (1996).Google Scholar
  4. 4.
    A. Genesca, R. Miro, M. R. Caballin,et al., Human Reprod.,5, No. 3, 286–290 (1990).Google Scholar
  5. 5.
    E. Keuser, N. Liros, and W. Hefzel,Cancer Res. Clin. Oncol., No. 3, 260–266 (1987).CrossRefGoogle Scholar
  6. 6.
    J.J. Kjer and T. Irersen,Br. J. Obstet. Gynaecol.,97, No. 7, 623–625 (1990).PubMedGoogle Scholar
  7. 7.
    D. Mormor,Contracept. Fertil. Sex.,21, No. 10, 739–743 (1993).Google Scholar
  8. 8.
    S. Retsas, H. Mackenzie, and A. Mohith,Lancet,347, No. 9002, 687 (1996).PubMedCrossRefGoogle Scholar
  9. 9.
    H. Schwabe,Dtsch. Med. Wochenschr., No. 4, 121–126 (1992).CrossRefGoogle Scholar
  10. 10.
    R. Sutton, A. U. Burdar, and G. N. Hortobagyl,Cancer,65, No. 4, 847–850 (1990).PubMedCrossRefGoogle Scholar
  11. 11.
    K. L. Witt and J. Bishop,Mutat. Res.,355, No. 1-2, 209–234 (1996).PubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • E. D. Gol'dberg
    • 1
  • T. G. Borovskaya
    • 1
  • M. E. Poluektova
    • 1
  1. 1.Institute of Pharmacology, Tomsk Research CenterSiberian Division of the Russian Academy of Medical SciencesUSSR

Personalised recommendations