Bulletin of Experimental Biology and Medicine

, Volume 129, Issue 4, pp 309–313 | Cite as

Oxidative stress in keratinocytes as an etiopathogenetic factor of psoriasis

  • V. N. ShilovEmail author
  • V. I. Sergienko


A new etiopathogenetic concept of psoriasis is proposed, which considers psoriasis as a typical inflammatory process characterized by increased antioxidant activity and overexpression of apoptotic receptors. Under these conditions, hyperstimulation of germinative layer cells proliferation dramatically accelerates kerationcyte passage towards apoptotic effect of atmospheric oxygen and its reactive species dooming to death cells with enhanced expression of apoptotic receptors. Oxidative stress of nondifferentiated kerationcytes triggers the formation of defective horny layer, the key mechanism of psoriasis.

Key Words

psoriasis apoptosis inflammation proliferation oxidative stress lipid peroxidation reactive oxygen species redox potential 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Yu. A. Vladimirov, O. A. Azizova, A. I. Deev,et al., Science and Technics Reviews, Biophysics [in Russian], Moscow (1991), vol. 29.Google Scholar
  2. 2.
    L. Ieger,Clinical Immunology and Allergology, [in Russian], Moscow (1990), vol. 3, pp. 445–448.Google Scholar
  3. 3.
    V. S. Marinov and R. Kh. Ziganshin,Biofizika,42, No. 1, 147–155 (1997).PubMedGoogle Scholar
  4. 4.
    E. B. Men'shikova, N. K. Zenkov, and S. M. SherginBiochemistry of Oxidative Stress (Oxidants and Antioxidants) [in Russian], Novosibirsk (1994), p. 130.Google Scholar
  5. 5.
    V. N. Mordovtsev, F. Yu. Prokhorov, I. V. Starkov, et al.,Vestn Dermatol., No. 7, 28–33 (1987).Google Scholar
  6. 6.
    V. S. Novikov, D. V. Bulavin, and V. N. Tsygan,Programmed Cell Death, [in Russian], Ed. V. S. Novikov, St. Petersburg (1996), pp. 30–50.Google Scholar
  7. 7.
    A. P. Novozhilova, N. N. Pluzhnikov, and V. S. Novikov,Ibid.,Programmed Cell Death, [in Russian], Ed. V. S. Novikov, St. Petersburg (1996), pp. 9–29.Google Scholar
  8. 8.
    Yu. N. Perlamutrov, L. M. Bordenshtein, and M. R. Taumin,Psoriasis [in Russian], Moscow (1980), pp. 39–43.Google Scholar
  9. 9.
    D. D. Petrunin, Yu. M. Lopukhin, and N. G. Korotkii,Immunologiya, No. 3, 50–52 (1995).Google Scholar
  10. 10.
    G. Ya. Sharapova, N. G. Korotkii, and M. N. Molodenkov,Psoriasis [in Russian], Moscow (1993), pp. 36–42.Google Scholar
  11. 11.
    V. N. Shilov and V. I. Sergienko,Efferentnaya Terapiya, No. 3, 16–20 (1997).Google Scholar
  12. 12.
    V. N. Shilov and V. I. Sergienko,Ibid., No. 4, 18–21 (1997).Google Scholar
  13. 13.
    V. N. Shilov and V. I. Sergienko,Vestn. Dermatol., No. 3, 26–32 (1998).Google Scholar
  14. 14.
    V. N. Shilov and Z. Yu. Tabukhov,Noninvasive Diagnostic Techniques [in Russian], Moscow (1995), p. 42.Google Scholar
  15. 15.
    M. R. Alderson, R. J. Armitage, E. Maraskovsy, et al.,J. Exp. Med., 178, 2231–2235 (1993).PubMedCrossRefGoogle Scholar
  16. 16.
    R. G. Allen and A. K. Balin,Free Radic. Biol. Med.,6, 623–661 (1989).CrossRefGoogle Scholar
  17. 17.
    L. H. Boise, M. Gonzales-Garcia, C. E. Postema, et al.,Cell, 74, 597–608 (1993).PubMedCrossRefGoogle Scholar
  18. 18.
    R. H. Burdon,J. Biol. Chem.,373, 739–740 (1992).Google Scholar
  19. 19.
    A. R. Clarke, C. A. Purdie, D. J. Harrison, et al.,Nature,362, 849–852 (1993).PubMedCrossRefGoogle Scholar
  20. 20.
    D. Crawford, I. Zbinden, P. Amstad, et al.,Oncogene,3, 849–852 (1988).Google Scholar
  21. 21.
    M. N. Falk, B. C. Tranth, K. M. Debatin, et al.,Blood,79, 3300–3306 (1992).PubMedGoogle Scholar
  22. 22.
    R. K. Fidelins,Cell Immunol. 113, 175–182 (1988).CrossRefGoogle Scholar
  23. 23.
    H. J. Galla,Angen. Chem.,32, 378–380 (1993).Google Scholar
  24. 24.
    D. Hockenbery, G. Nunes, C. Milliman, et al.,Nature,348, 334–336 (1990).PubMedCrossRefGoogle Scholar
  25. 25.
    I. Giardino, D. Edelstein, and M. Blownlee,J. Clin. Invest.,97, No. 6, 1422–1428 (1996).PubMedCrossRefGoogle Scholar
  26. 26.
    D. M. Hockenbery, Z. N. Oltval, X.-M. Yin, et al.,Cell,75, 241–251 (1993).PubMedCrossRefGoogle Scholar
  27. 27.
    M. D. Jacobson,Talking Point (1996), pp. 83–86.Google Scholar
  28. 28.
    P. H. Krammer, J. Behrmann, P. Daniel, et al.,Curr. Opin. Immunol.,6, 279–289 (1994).PubMedCrossRefGoogle Scholar
  29. 29.
    E. Y. Lin, A. Orlofsky, M. S. Berger, and M. B. Prystowsky,J. Immunol.,151, 1979–1988 (1993).PubMedGoogle Scholar
  30. 30.
    Z.-G. Liu, S. W. Smith, K. A. McLAughlin, et al.,Nature,367, 281–284 (1994).PubMedCrossRefGoogle Scholar
  31. 31.
    S. W. Lowe, E. M. Schmitt, S. W. Smith, et al.,Ibid.,362, 847–849 (1993).PubMedCrossRefGoogle Scholar
  32. 32.
    F. Miller,Free. Radic. Biol. Med.,13, 651–657 (1992).CrossRefGoogle Scholar
  33. 33.
    S. Moncada,J. Lab. Clin. Med.,120, 187–191 (1992).PubMedGoogle Scholar
  34. 34.
    S. Moncada, R. M. J. Palmer, and E. A. Higgs,Pharmacol. Rev.,43, 109–142 (1991).PubMedGoogle Scholar
  35. 35.
    A. Oehm, I. Behrmann, W. Falk, et al.,J. Biol. Chem.,267, 10709–10715 (1992).PubMedGoogle Scholar
  36. 36.
    Z. N. Oltvai, C. L. Milliman, and S. J. Korsmeyer,Cell,74, 609–619 (1993).PubMedCrossRefGoogle Scholar
  37. 37.
    C. M. Rubanyi,Free. Radic. Biol. Med.,4, 107–121 (1988).PubMedCrossRefGoogle Scholar
  38. 38.
    L. W. Schwarts and B. A. Ochborn,Immunol. Today,12, 582–590 (1993).CrossRefGoogle Scholar
  39. 39.
    Y. Shi, J. M. Glynn, L. J. Guilbert, et al.,Science,257, 212–224 (1992).PubMedGoogle Scholar
  40. 40.
    Y. Soini, D. Kamel, P. Paakko, et al.,Br. J. Dermatol.,131, No. 4, 514–520 (1994).PubMedCrossRefGoogle Scholar
  41. 41.
    C. B. Thompson,Science,267, No. 503, 1456–1462 (1995).PubMedGoogle Scholar
  42. 42.
    A. Verma, D. J. Hirsch, C. E. Glatt, et al.,Science,259, 381–384 (1993).PubMedGoogle Scholar
  43. 43.
    H. Wein,Med. Hypotheses,39, 267–270 (1992).CrossRefGoogle Scholar
  44. 44.
    C. A. Whiteacre and M. K. Cathcart,Cell. Immunol.,144, 287–295 (1992).CrossRefGoogle Scholar
  45. 45.
    T. Wrone-Smith, T. Johnson, B. Nelson, et al.,Am. J. Pathol.,146, No. 5, 1079–1088 (1995).PubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  1. 1.Institute of Physicochemical MedicineRussian Ministry of HealthMoscow

Personalised recommendations