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Bulletin of Experimental Biology and Medicine

, Volume 129, Issue 4, pp 309–313 | Cite as

Oxidative stress in keratinocytes as an etiopathogenetic factor of psoriasis

  • V. N. ShilovEmail author
  • V. I. Sergienko
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Abstract

A new etiopathogenetic concept of psoriasis is proposed, which considers psoriasis as a typical inflammatory process characterized by increased antioxidant activity and overexpression of apoptotic receptors. Under these conditions, hyperstimulation of germinative layer cells proliferation dramatically accelerates kerationcyte passage towards apoptotic effect of atmospheric oxygen and its reactive species dooming to death cells with enhanced expression of apoptotic receptors. Oxidative stress of nondifferentiated kerationcytes triggers the formation of defective horny layer, the key mechanism of psoriasis.

Key Words

psoriasis apoptosis inflammation proliferation oxidative stress lipid peroxidation reactive oxygen species redox potential 

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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  1. 1.Institute of Physicochemical MedicineRussian Ministry of HealthMoscow

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