Bulletin of Experimental Biology and Medicine

, Volume 128, Issue 3, pp 888–889 | Cite as

Effects of bioglycans isolated from birch fungiinonotus obliquus on electric activity of venous sinus cells in frog heart

  • V. A. Golovko


Bioglycans isolated from chaga in a concentration of 0.0001% reduced frequency of action potential in venous sinus cells of frog heart during the first 15–30 min of exposure, then this parameter increased by 10% per hour over 3.5 h, and was 41±3 min−1 from the 4th to the 20th hour of incubation. The frequency of action potentials in heart strips in the chaga extract was 40% higher than in Ringer's solution. The effect of chaga bioglycan is probably associated with adsorption on myocyte membranes. Binding of Ca2+ to bioglycans observed during the first 30 min inhibited efflux of intracellular Ca2+.

Key Words

chag bioglycans action potential pacemaker 


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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • V. A. Golovko
    • 1
  1. 1.Laboratory of Physiological Researches, Department of Biotechnology and Molecular Immunology, Institute of Physiology, Komi Research CenterUral Division of the Russian Academy of SciencesSyktyvkar

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