Bulletin of Experimental Biology and Medicine

, Volume 129, Issue 6, pp 544–546

Dimebon improves learning in animals with experimental Alzheimer's disease

  • N. N. Lermontova
  • N. V. Lukoyanov
  • T. P. Serkova
  • E. A. Lukoyanova
  • S. O. Bachurin
Pharmacology and Toxicology

DOI: 10.1007/BF02434871

Cite this article as:
Lermontova, N.N., Lukoyanov, N.V., Serkova, T.P. et al. Bull Exp Biol Med (2000) 129: 544. doi:10.1007/BF02434871

Abstract

Systemic administration of antihistamine drug dimebon improves active avoidance conditioning in rats with chronic partial deprivation of cerebral cholinergic functions caused by intracerebroventricular injections of AF64A. The effects of dimebon on learning are similar to those of tacrine used in the treatment of Alzheimer's disease.

Key words

dimebon H1receptor inhibitor tacrine AF64A avoidance conditioning rats 

Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • N. N. Lermontova
    • 1
  • N. V. Lukoyanov
    • 1
  • T. P. Serkova
    • 1
  • E. A. Lukoyanova
    • 1
  • S. O. Bachurin
    • 1
  1. 1.Laboratory of Neurochemistry, Institute of Physiologically Active SubstancesRussian Academy of SciencesChernogolovka, Moscow Region

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