Bulletin of Experimental Biology and Medicine

, Volume 129, Issue 2, pp 184–185 | Cite as

Involvement of angiotensin II system components in regulation of DNA synthesis in pyloric epithelium of albino rats

  • S. S. Timoshin
  • E. Yu. Zhivotova
Experimental Biology
Received:
  • 20 Downloads

Abstract

Effects of intraperitoneal injections of angiotensin II and oral intake of cosaar (angiotensin II receptor blocker) and ednite (angiotensin-converting enzyme inhibitor) on DNA synthesis in the pyloric portion of the stomach was studied in adult albino rats by autoradiography with3H-thymidine. Proliferative processes in the studied tissue were enhanced 24 h after single injection of the peptide in a dose of 50 μg/kg and 4 h after injection of 100 μg/kg peptide. Treatment with cosaar and ednite for 2 weeks led to normalization of stress-activated epithelial proliferation in the pyloric part of the stomach.

Key Words

agiotensin II cosaar ednite stomach DNA synthesis 
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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • S. S. Timoshin
    • 1
  • E. Yu. Zhivotova
    • 1
  1. 1.Central Research LaboratoryFar-Eastem State Medical UniversityKhabarovsk

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