Bulletin of Experimental Biology and Medicine

, Volume 129, Issue 3, pp 271–274 | Cite as

Accumulation of factor stimulating glial proliferation in aging mammalian brain

  • V. A. Zuev
  • I. V. Victorov
  • N. P. Borodina
  • N. G. Ignatova
  • S. I. Bykovskaya
  • A. S. Khalanskii
Microbiology and Immunology


Extract from the brain of young mice produced weak cytoproliferative effect on cultured glial cells, while brain extract from old mice 3–4- and 30–60-fold stimulated glial proliferation in primary and passaged cell cultures, respectively.

Key Words

cell culture gliosis brain aging prion diseases 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    V. A. Zuev, I. A. Zavalishin, and V. M. Roikhel',Prion Diseases of Humans and Animals, Moscow (1999).Google Scholar
  2. 2.
    E. Beck and P. M. Daniel, in:Prions, Eds. S. Prusiner and M. P. McKinley, New York (1987), pp. 331–385.Google Scholar
  3. 3.
    D. R. Brown, B. Schmidt, and H. A. Kretzschmar,Nature,380, 345–347 (1996).PubMedCrossRefGoogle Scholar
  4. 4.
    M. E. Bruce, P. A. McBridge, M. Jeffrey,et al., in:Alzheimer's Disease: Advances in Clinical and Basic Research, New York (1993), pp. 481–487.Google Scholar
  5. 5.
    H. Fraser and P. A. McBridge, in:Senile Dementia of the Alzheimer Type, Eds. J. Traber and W. H. Gispen, Berlin (1985), pp. 250–268.Google Scholar
  6. 6.
    D. Goldgaber, M. I. Lerman, W. O. VcBride,et al., J. Neural Transm.,24, 23–28 (1987).Google Scholar
  7. 7.
    D. C. Guiroy, I. Wakayama, P. Liberski,et al., Acta Neuropathol. (Berl.),87, 447–450 (1994).Google Scholar
  8. 8.
    P. Eikelenboom, S. S. Zhan, W. A. Wan Gool,et al., Trends Neurosci.,15, 447–450 (1994).Google Scholar
  9. 9.
    K. Hikita, J. Tateischi, and H. Nagara,Acta Neuropathol. (Berl.),68, 138–144 (1985).CrossRefGoogle Scholar
  10. 10.
    J. Ironside and J. Bell, in:Prion Diseases, Eds. J. Collinge and M. Halmer, Oxford (1997), pp. 57–88.Google Scholar
  11. 11.
    S. Itagaki, P. L. McGeer, H. Akiyama,et al., J. Neuroimmunol.,2, 173–182 (1989).CrossRefGoogle Scholar
  12. 12.
    C. L. Masters, G. Malthaup, G. Simms,et al., EMBO J.,4, 2757–2763 (1985).PubMedGoogle Scholar
  13. 13.
    Transmissible Subacute Spongiform Enchephalopathies, Eds. L. Court and B. Dodet, Paris (1996).Google Scholar
  14. 14.
    H. M. Wisniewski, A. W. Verbrodt, R. C. Moretz,et al., Exp. Brain Res.,5, Suppl., 3–9 (1982).PubMedGoogle Scholar
  15. 15.
    H. M. Wisniewski, M. Barcikowska, and E. Kida,Acta Neuropathol. (Berl.),81, 588–590 (1991).CrossRefGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • V. A. Zuev
    • 1
  • I. V. Victorov
    • 2
  • N. P. Borodina
    • 1
  • N. G. Ignatova
    • 1
  • S. I. Bykovskaya
    • 1
  • A. S. Khalanskii
    • 3
  1. 1.N. F. Gamaleya Institute of Epidemiology and MicrobiologyRussian Academy of Medical SciencesMoscow
  2. 2.Brain Research InstituteRussian Academy of Medical SciencesMoscow
  3. 3.Institute of Human MorphologyRussian Academy of Medical SciencesMoscow

Personalised recommendations