Effects of hormones on phospholipase A2 activity in rat skin
Pharmacology and Toxicology
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Abstract
We studied the effects of hydrocortisone, progesterone, estradiol, and testosterone on phospholipase A2 activity in plasma and lysosomal membranes of rat dermis and epidermis. The dermal enzyme was more sensitive to estradiol, while epidermal to testosterone. The effects of progesterone and hydrocortisone were mediated by lipocortin-like protein, while estradiol and testosterone directly by modulated phospholipase A2 activity
Key Words
skin dermis epidermis estradiol hydrocortisone progesterone testosterone phospholipase A2Preview
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References
- 1.Ya. D. Kirshenblatt,Practicum in Endocrinology [in Russian], Moscow (1969), pp. 77–79.Google Scholar
- 2.Yu. K. Skripkin, A. L. Mashkilleison, and G. Ya. Sharapova,Skin and Venereal Diseases [in Russian], Moscow (1997).Google Scholar
- 3.J. Tepperman, H. M. Tepperman,Metabolic and Endocrine Physiology, Chicago-London (1987).Google Scholar
- 4.A. White,Immunology [Russian translation] Moscow (1989), pp. 357–359.Google Scholar
- 5.T. V. Ukhina and M. M. Shegai,Byull. Eksp. Biol. Med.,115, No. 3, 265–267 (1993).CrossRefGoogle Scholar
- 6.F. Hirata,Calcium and Cell Function, Ed. W. Y. Cheung, New York (1984), Vol. 5, pp. 279–290.Google Scholar
- 7.O. H. Lowry, N. J. Rosebrough, A. L. Farr,et al., J. Biol. Chem.,193, 265–275 (1951).PubMedGoogle Scholar
- 8.H. Winkleret al., Biochem. J.,105, 38–46 (1967).Google Scholar
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