Immunoenzyme assay of glycocalicin, platelet glycoprotein Ib fragment. Evaluation of platelet turnover in circulation and differential diagnosis of thrombocytopenia
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Abstract
We propose a method for measurement of plasma glycocalicin, a fragment of platelet membrane glycoprotein Ib. The concentration of glycocalicin is elevated in thrombocythemia and reduced in thrombocytopenia caused by insufficient platelet production, but not in immune thrombocytopenia due to enhanced platelet degradation. Thus, plasma content of glycocalicin is an indicator of platelet turnover. The proposed assay can be used for differential diagnostics of thrombocytopenia.
Key Words
platelets thrombocytopenia thrombocythemia glycocalicin immunoenzyme assayPreview
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© Kluwer Academic/Plenum Publishers 2000