European Journal of Pediatrics

, Volume 145, Issue 6, pp 570–571 | Cite as

Megaloblastic anaemia in one of monozygous twins breast fed by their vegetarian mother

  • R. C. Gambon
  • M. J. Lentze
  • E. Rossi
Case Reports

Abstract

Megaloblastic anaemia in infancy is uncommon in western countries. We describe a case of an exclusively breast-fed monozygous twin with severe vitamin B12 deficiency with haematologic and neurologic abnormalities. Treatment with vitamin B12 resulted in a rapid haematological and clinical improvement.

Key words

Alimentary vitamin B12 deficiency Vegetarianism Megaloblastic anaemia 

References

  1. 1.
    Davis JR, Goldenring J, Lubin BH (1981) Nutritional vitamin B12 deficiency in infants. Am J Dis Child 135:566PubMedGoogle Scholar
  2. 2.
    Fonti FE (1960) Considerazioni su 102 casi di anemia perniciosiforme del lattante, osservati nel decennio 1950–1959. Pediatria 68:574PubMedGoogle Scholar
  3. 3.
    Food and Nutrition Board (1974) Recommended Dietary Allowances. National Academy of Sciences, Washington D.C.Google Scholar
  4. 4.
    Higginbottom MC, Sweetman L, Nyhan WL (1978) A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin B12-deficient breast-fed infant of a strict vegetarian. N Engl J Med 299:317PubMedCrossRefGoogle Scholar
  5. 5.
    Hoey H, Linnell JC, Oberholzer VG, Laurance BM (1982) Vitamin B12 deficiency in a breastfed infant of a mother with pernicious anemia. J R Soc Med 75(8):656PubMedGoogle Scholar
  6. 6.
    Jadhav M, Webb JKG, Vaishnava S, Baker SJ (1962) Vitamin B12 deficiency in Indian infants. Lancet 2:903PubMedCrossRefGoogle Scholar
  7. 7.
    Lacroix J, Macher MA, Badoual J, Huault G (1981) Complications d'une diète végétarienne chez une enfant nourrie au sein. Arch Fr Pediatr 38:238Google Scholar
  8. 8.
    Lampkin BC, Saunders EF (1969) Nutritional vitamin B12 deficiency in an infant. J Pediatr 75:1053PubMedCrossRefGoogle Scholar
  9. 9.
    Luhby AL, Cooperman JM, Stone ML, Slobody LB (1961) Physiology of vitamin B12 in pregnancy, the placenta, and the newborn. Am J Dis Child 102:753Google Scholar
  10. 10.
    Wighton MC, Manson JI, Speed I, Robertson E, Chapman E (1979) Brain damage in infancy and dietary vitamin B12 deficiency. Med J Aust 2:1PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • R. C. Gambon
    • 1
  • M. J. Lentze
    • 1
  • E. Rossi
    • 1
  1. 1.Department of Pediatrics, Children's HospitalUniversity of BerneBerneSwitzerland
  2. 2.Universitäts-FrauenklinikBernSwitzerland

Personalised recommendations