Calcified Tissue International

, Volume 33, Issue 1, pp 583–586 | Cite as

Variations in mineral apposition rate of trabecular bone within the beagle skeleton

  • T. J. Wronski
  • J. M. Smith
  • W. S. S. Jee
Laboratory Investigation


The mineral apposition rate of trabecular bone was determined in several skeletal sites of young adult beagles. Tetracycline derivatives were administered intravenously or orally on 2 separate occasions preceding the day of sacrifice in order to label actively mineralizing bone surfaces. The rate of mineral apposition was calculated by dividing the distance between the 2 tetracycline markers by the time interval between their administration. The lumbar vertebra, proximal humerus, and pelvis, each of which contains red marrow, were found to have a significantly higher (P<0.001) rate of mineral apposition in trabecular bone than the skeletal sites containing yellow marrow—the proximal ulna and distal humerus. The mean apposition rate in the former 3 sites was 1.3±0.3µm/day, while that in the latter 2 was 0.9±0.2µm/day (uncorrected for plane of sectioning). It is tempting to speculate that this finding may be a consequence of differences in vascularity between red and yellow marrow.

Key words

Tetracycline Trabecular bone Mineral apposition rate Bone marrow Vascularity 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • T. J. Wronski
    • 1
  • J. M. Smith
    • 1
  • W. S. S. Jee
    • 1
  1. 1.Department of Pharmacology, Radiobiology DivisionUniversity of Utah College of MedicineSalt Lake CityUSA
  2. 2.Biomedical Research DivisionNASA Ames Research CenterMoffett FieldUSA

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