Journal of Autism and Developmental Disorders

, Volume 10, Issue 2, pp 129–137

Ineffectiveness of imipramine in children who fail to respond to methylphenidate

  • Bertrand G. Winsberg
  • Samuel S. Kupietz
  • Luis E. Yepes
  • Stanley Goldstein
Article

DOI: 10.1007/BF02408464

Cite this article as:
Winsberg, B.G., Kupietz, S.S., Yepes, L.E. et al. J Autism Dev Disord (1980) 10: 129. doi:10.1007/BF02408464

Abstract

Ten hyperactive children who had failed to respond to methylphenidate were treated with imipramine in a placebo-controlled, crossover design. No significant drug effects were obtained either on parent and teacher ratings of the child's behavior or on the child's performance in a laboratory measure of sustained attention. Findings suggest that imipramine has limited clinical usefulness in the treatment of hyperactive children who fail to respond to methylphenidate.

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Bertrand G. Winsberg
    • 1
    • 2
  • Samuel S. Kupietz
    • 1
    • 2
  • Luis E. Yepes
    • 1
    • 2
  • Stanley Goldstein
    • 3
  1. 1.Long Island Research Institute, Health Science CenterState University of New York at Stony BrookStony Brook
  2. 2.Department of PsychiatryState University of New York at Stony BrookStony Brook
  3. 3.Downstate Medical CenterUSA

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