Ineffectiveness of imipramine in children who fail to respond to methylphenidate
- Cite this article as:
- Winsberg, B.G., Kupietz, S.S., Yepes, L.E. et al. J Autism Dev Disord (1980) 10: 129. doi:10.1007/BF02408464
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Ten hyperactive children who had failed to respond to methylphenidate were treated with imipramine in a placebo-controlled, crossover design. No significant drug effects were obtained either on parent and teacher ratings of the child's behavior or on the child's performance in a laboratory measure of sustained attention. Findings suggest that imipramine has limited clinical usefulness in the treatment of hyperactive children who fail to respond to methylphenidate.