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Hyperfine Interactions

, Volume 61, Issue 1–4, pp 1201–1204 | Cite as

111Cd TDPAC investigation of metal sites in superoxide dismutase: A comparison with X-ray diffraction data

  • R. Bauer
  • M. Bjerrum
  • E. Danielsen
  • P. Kofod
Article

Abstract

111Cd Time Differential Ferturbed γ-γ Angular Correlation (TDPAC) has been used to investigate the Zn-site in Cu2, Zn2-superoxide dismutase. These experiments show a clear difference between Cu(II)2 Cd2 SOD and Cu(I)2Cd2SOD. The result of Cu(II)2, Cd2-SOD agrees with the Angular Overlap Model (AOM) applied to the known crystal structure using known partial field gradients for the ligands involved, whereas the results from the experiments with Cu(I) show that a significant conformational change must have taken place at the Zn-site. A proposal for this conformational change has been achieved by computer-modelling.

Keywords

Thin Film Crystal Structure Superoxide Superoxide Dismutase Conformational Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© J.C. Baltzer A.G., Scientific Publishing Company 1990

Authors and Affiliations

  • R. Bauer
    • 1
  • M. Bjerrum
    • 2
  • E. Danielsen
    • 1
  • P. Kofod
    • 2
  1. 1.Department of PhysicsRoyal Veterinary and Agricultural UniversityFrederiksberg CDenmark
  2. 2.Department of ChemistryRoyal Veterinary and Agricultural UniversityFrederiksberg CDenmark

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