Age changes in bone mineralization, cortical thickness, and Haversian canal area
- 453 Downloads
Age-related changes in femoral cortical bone were quantified in an age-graded series of human cadavers. Variables included in this study were cortical thickness, bone mineral content, cortical bone density, summed Haversian canal area, Haversian canal number, and mean Haversian canal area. Females showed significant (P<0.05) decreases in cortical thickness, bone mineral content, and cortical bone density when plotted against age. Males exhibited slight nonsignificant declines for cortical thickness, bone mineral content, and cortical bone density. Both males and females exhibited significant (P<0.05) age-related increases in summed Haversian canal area values and Haversian canal number. Females as a group were found to exhibit significantly (P<0.05) larger mean Haversian canal area values compared with males, but the male group exhibited more Haversian canals per unit area of cortical bone compared with females.
Intercorrelations between the bone mineral index and summed Haversian canal area and between cortical bone density and summed Haversian canal area define the role of increasing Haversian canal number and mean canal size per unit area of cortical bone as a factor in the reduction of bone mass as a function of age. Partial correlations between the bone mass variables and the variables assessing Haversian canal size and number further support this argument.
Key wordsAbsorptiometry Cortical thickness Bone mineral Haversian canal
Unable to display preview. Download preview PDF.
- 1.Garn, S.M.: The Earlier Gain and the Later Loss of Cortical Bone. Charles C Thomas, Springfield, Ill., 1970Google Scholar
- 4.Mazess, R.B., Cameron, J.R.: Bone mineral content in normal U.S. whites. In R.B. Mazess (ed.): Proceedings of the International Conference on Bone Mineral Measurement, pp. 228–238. U.S. Government Printing Office, Washington, D.C., 1973Google Scholar
- 6.Thompson, D.D.: Age-related changes in osteon remodeling and bone mineralization, Ph.D. Dissertation, University of Connecticut, Storrs, 1978Google Scholar
- 9.Jowsey, J.: Age changes in human bone, Clin. Orthop.17:210–217, 1960Google Scholar
- 12.Dequeker, J.: Bone Loss in Normal and Pathological Conditions. Leuven University Press, Leuven, Belgium, 1972Google Scholar