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Evozierte Enthemmung und Bahnungsminderung in corticalen Nervenzellen

Intracelluläre Ableitungen vom sensomotorischen Cortex der Katze

Evoked disinhibition and disfacilitation in neurons of the cat's sensorimotor cortex

Intracellular recordings

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Summary

In pyramidal cells of the cat's sensorimotor cortex two kinds of hyperpolarization i.e. of either short (less than 100 msec) or long duration (up to 200 msec or more) can be evoked. Both begin with an inhibitory postsynaptic potential (IPSP) of up to 60 msec duration, which consists of a series of single steps which can be in phase with the intervals between action potentials of high frequency discharges probably from interneurons.

The IPSP of evoked hyperpolarization ofshort duration is followed by adisinhibition which obviously corresponds to a discharging pause of inhibitory interneurons which are responsible for establishing a tonic background inhibition on pyramidal cells.

The IPSP of evoked hyperpolarization oflong duration is followed by disfacilitation in addition to the disinhibition. Thedisfacilitation might be caused by an inhibition of excitatory interneurons which are responsible for establishing a tonic background excitation on pyramidal cells. The long-duration hyperpolarization is followed bylate facilitation which can last up to 600 msec.

Zusammenfassung

In Pyramidenzellen des sensomotorischen Cortex der Katze lassen sich zwei Arten reizbedingter Hyperpolarisation unterschiedlicher Dauer auslösen. Beide beginnen mit einem inhibitorischen postsynaptischen Potential (IPSP), das bis zu 60 msec andauern kann. Es wird aus einzelnen IPSP-Stufen aufgebaut, die zeitlich mit den Aktionspotentialen hochfrequent entladender Zwischenneurone übereinstimmen können.

Bei derkurzdauernden Hyperpolarisation (unter 100 msec) folgt den IPSP eineEnthemmung (Disinhibition), offenbar als Folge einer Entladungspause in solchen hemmenden Zwischenneuronen, die eine tonische Hintergrundhemmung auf Pyramidenzellen ausüben.

Bei derlangdauernden Hyperpolarisation (200 msec und mehr) folgt den IPSP außer einer Enthemmung zusätzlich eineBahnungsminderung (Disfacilitation), vermutlich wegen einer Hemmung in erregenden Zwischenneuronen, die tonisch erregend auf Pyramidenzellen einwirken. Der evozierten langdauernden Hyperpolarisation schließt sich einespäte Bahnung (Facilitation) an, die bis zu 600 msec andauern kann.

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  1. Abteilung für experimentelle Neuropsychiatrie in der Universitäts-Nervenklinik mit Poliklinik, Erlangen

    Jürgen Vieth, Ullrich Kneise & Johanna Käferlein

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  1. Jürgen Vieth
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  2. Ullrich Kneise
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  3. Johanna Käferlein
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Unterstützt von der Deutschen Forschungsgemeinschaft (Vi 36/1-5).

Die Deutsche Forschungsgemeinschaft gewährte dankenswerterweise eine großzügige finanzielle Unterstützung (Vi 36/1-5). Eine große Hilfe war der umfangreiche Literaturdienst von: University of California Brain Information Service, part of the NINDS Neurological Information Network, supported by contract No. 70-2063; und von: Parkinson's Disease & Related Disorders, Citations from the Literature, supported by NINDS Neurological Information Network.

Herrn Dr. M. R. Klee, Max Planck-Institut für Hirnforschung, Frankfurt/Main, sei besonders für die Diskussion der Befunde gedankt.

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Vieth, J., Kneise, U. & Käferlein, J. Evozierte Enthemmung und Bahnungsminderung in corticalen Nervenzellen. Arch. F. Psychiatr. U. Z. Neur. 218, 271–290 (1974). https://doi.org/10.1007/BF02401385

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