Biochemical Genetics

, Volume 30, Issue 3–4, pp 113–121

Glucose-6-phosphate dehydrogenase deficiency and sulfadimidin acetylation phenotypes in Egyptian oases

  • Laila Hussein
  • Gamal Yamamah
  • Adly Saleh
Article

Abstract

Screening of 1315 males from two Egyptian oases for glucose-6-phosphate dehydrogenase deficiency (G-6PD) found an incidence of 5.9%. The rate of acetylation of sulfadimidin was also studied, and a bimodal distribution was found with 73% rapid acetylators. There is a correlation between high frequency of G-6PD deficiency and high frequency of slow acetylation rate.

Key words

population study glucose-6-phosphate dehydrogenase deficiency drug acetylation polymorphism Egyptian oasis 

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References

  1. Belsey, M. (1973). The epidemiology of Favism.Bull. WHO 481.PubMedGoogle Scholar
  2. Beutler, E. (1966). A series of new screening procedures for pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase deficiency and glutathione reductase deficiency.Blood 28553.PubMedGoogle Scholar
  3. Bottini, E., Lucarelli, P., Agostino, R., Palmarino, R., Businco, L., and Antognoni, G. (1971). Favism: Association with erythrocyte acid phosphatase phenotype.Science 171409.PubMedGoogle Scholar
  4. Bratton, A., and Marshall, E. (1939). A new coupling component for sulfanilamide determination.J. Biol. Chem. 128537.Google Scholar
  5. Brewer, G. (1986). Pharmacogenetic interaction glucose-6-phosphate dehydrogenase deficiency with acetylation and hydroxylation. In Yoshida, A., and Beutler, E. (eds.),Glucose-6-phosphate Dehydrogenase Academic Press, New York, pp. 13–23.Google Scholar
  6. Carson, P., Flanagan, C., Ickes, C., and Alving, A. (1956). Enzyme deficiency in primaquine sensitive erythrocytes.Science 124484.PubMedGoogle Scholar
  7. Cartwright, R. A., Ahmed, R. A., and Rogess, H. J. (1984). N-acetyltransferase phenotypes in Iraqui and British population.Hum. Hered. 34101.PubMedGoogle Scholar
  8. Dern, R., Beutler, E., and Alving, A. (1981). The hemolytic effect of primaquine.J. Lab. Clin. Med. 97751.Google Scholar
  9. Evans, D., Manley, K., and McKusick, V. (1960). Genetic control of isoniazid metabolism in man.Br. Med. J. 2185.CrossRefGoogle Scholar
  10. Fessas, P., Doxiadis, S., and Valaes, T. (1962). Neonatal Jaundice in G-6PD deficient infants.Br. Med. J. 111359.Google Scholar
  11. Fiorelli, G., Finazzi, G., Manoussakis, C., Palomba, V., and Fenu, M. (1982). G-6PD deficiency in Sardinia: Genetic heterogeneity and clinical implications. In Weatherallet al. (eds.),Adv. Red Cell Biol. Raven Press, New York, pp. 399–408.Google Scholar
  12. Frymoyer, J., and Jacox, R. (1963). Investigation of the genetic control of sulfadiazine and isoniazid metabolism in the rabbit.J. Lab. Clin. Med. 62891.PubMedGoogle Scholar
  13. Hoo, J., Hussein, L., and Goedde, H. (1977). A simplified micromethod for the determination of the acetylator phenotype.J. Clin. Chem. Biochem. 15329.Google Scholar
  14. Hrdlicka, A. (1912). The natives of Kharga Oasis, Egypt.Smithson. Misc. Coll. 591.Google Scholar
  15. Karim, A. K., El-Fellah, M. S., and Evans, D. A. (1981). Human acetylator polymorphism: Estimate of allele frequency in Libya and details of global distribution.J. Med. Genet. 18325.PubMedGoogle Scholar
  16. Magon, A., Leipzig, R., Zannoni, V., and Brewer, G. (1981). Interactions of glucose-6-phosphate dehydrogenase deficiency with drug acetylation and hydroxylation reactions.J. Lab. Clin. Med. 97764.PubMedGoogle Scholar
  17. McCaffrey, R., Halsted, C., and Abdel Wahab, M. (1971). Chloramphenicol-induced hemolysis in Caucasian glucose-6-phosphate dehydrogenase deficiency.Ann. Intern. Med. 74722.PubMedGoogle Scholar
  18. McCaffrey, R., Farid, Z., and Kent, D. (1972). Acute hemolysis with Ambilhar treatment in glucose-6-phosphate dehydrogenase deficiency.Trans. Roy. Soc. Trop. Med. Hyg. 66795.CrossRefPubMedGoogle Scholar
  19. McCurdy, P., Kamel, K., and Selim, O. (1974). Heterogeneity of red cell glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in Egypt.J. Lab. Clin. Med. 84673.PubMedGoogle Scholar
  20. Motulsky, A. (1964). Hereditary red cell traits and malaria.Am. J. Trop. Med. 13147.Google Scholar
  21. Selim, O., Kamel, K., Azim, A., Gaballah, F., Sabry, F., Ibrahim, W., Moafy, N., and Hoerman, K. (1974). Genetic markers and anthropometry in the populations of the Egyptian Oases of El-Kharga and El-Dakhla.Hum. Hered. 24259.PubMedCrossRefGoogle Scholar
  22. Stamatoyannopoulos, G., Fraser, G., Motulsky, A., Fessas, P. H., Akrivakis, A., and Papayanopoulou, T. H. (1966). On the familial predisposition to favism.Am. J. Hum. Genet. 18253.PubMedGoogle Scholar
  23. Weber, W., and Brenner, W. (1974). A filter paper method for determining isoniazid acetylator phenotype.Am. J. Hum. Genet. 26467.PubMedGoogle Scholar
  24. Weber, W., and Hein, D. W. (1985). N-Acetylation pharmacogenetics.Am. Soc. Pharm. Exp. Ther. 3725.Google Scholar
  25. Yoshida, A., and Beutler, E. (eds.) (1986).Glucose-6-phosphate Dehydrogenase Academic Press, New York.Google Scholar

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Laila Hussein
    • 1
  • Gamal Yamamah
    • 1
  • Adly Saleh
    • 1
  1. 1.Nutrition LaboratoryNational Research CentreGizaEgypt

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