Archives of Gynecology and Obstetrics

, Volume 252, Issue 2, pp 99–102 | Cite as

Treatment of lymphangioleiomyomatosis by ovariectomy, interferon alpha 2b and tamoxifen — a case report

  • M. Klein
  • O. Krieger
  • R. Ruckser
  • A. Rosen
  • R. Waldner
  • P. Preis
  • A. Beck
Case Reports


The gender-specific prevalence of lymphangioleiomyomatosis (LAM) in premenopausal women suggests a hormonal etiology. Despite the antiestrogenic treatment (ovariectomy, tamoxifen) this disease is often refractory to therapy and almost inevitably leads to the patient's death. We describe a case where the antiproliferative effect of systemically applied interferon alpha 2b was successfully employed in addition to ovariectomy and the patient reached complete remission.

Key words

Lymphangioleiomyomatosis Interferon alpha 2b 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • M. Klein
    • 1
  • O. Krieger
    • 2
  • R. Ruckser
    • 3
  • A. Rosen
    • 4
  • R. Waldner
    • 5
  • P. Preis
    • 6
  • A. Beck
    • 1
  1. 1.Department of Gynecology and ObstetricsHanusch-KrankenhausViennaAustria
  2. 2.1st Medical Department, Krankenhaus der Elisabethinen, LinzLudwig Boltzmann Institute for Leukemia-research and Hematology, Hanusch-KrankenhausViennaAustria
  3. 3.2nd Medical DepartmentDonauspital SMZ OstViennaAustria
  4. 4.Department of Gynecology and ObstetricsDonauspital SMZ OstViennaAustria
  5. 5.3rd Medical DepartmentHanusch-KrankenhausVienna
  6. 6.Medical DepartmentKrankenhaus Waidhofen a.d. ThayaAustria

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