[18F]FDG synthesis by Anatech RB-86 robotic system: Improvements and general considerations

  • A. Bogni
  • C. Pascali
  • R. Iwata
  • A. Cavalleri
  • V. de Sanctis
  • D. Decise
  • G. Cucchetti
  • F. Crippa
  • C. Chiesa
  • M. Schiavini
  • M. Schiavini
  • E. Bombardieri
Article
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Abstract

A series of changes and updatings to the [18F]FDG setup of the Anatech RB-86 robotic system are described. They include improved [18O]H2O recovery, “one-pot” reaction, elimination of the SPE step and base-assisted hydrolysis. Considerations on this last point are also reported. Thus, a remarkable improvement in the radiochemical yield, which is now 81% (decay corrected to SOS) with a synthesis time of just 40 minutes, has been achieved. The influence of several different reaction vessel materials on the synthesis is also briefly examined.

Keywords

Physical Chemistry Hydrolysis Inorganic Chemistry Robotic System Reaction Vessel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    K. Hamacher, G. Blessing, B. Nebeling, Appl. Radiation Isotopes, 41 (1990) 49.Google Scholar
  2. 2.
    C. Pascali, V. de Sanctis., C. Chiesa, A. Bogni, F. Crippa, R. Marchesini, E. Bombardier, Appl. Radiation Isotopes, 47 (1996), 717.CrossRefGoogle Scholar
  3. 3.
    D. L. Alexoff, J. S. Fowler, S. J. Gatley, Appl. Radiation Isotopes, 42 (1991) 1189.Google Scholar
  4. 4.
    F. Fuchtner, J. Steinbach, P. Mading, B. Johannsen, Appl. Radiation Isotopes, 47 (1996) 61.Google Scholar
  5. 5.
    European Pharmacopoeia Commission: Guideline for Residual Solvent Levels in Drug Substances and Excipients Used for the Preparation of Medicinal Products, Document PA/PH/SG (94) 143.Google Scholar
  6. 6.
    P. Varelis, R. K. Barnes, Appl. Radiation Isotopes, 47 (1996) 731.CrossRefGoogle Scholar
  7. 7.
    C. J. S. Van Rijn, J. D. M. Herscheid, G. W. M. Visser, A. Hoekstra, Appl. Radiation Isotopes, 36 (1985) 111.Google Scholar
  8. 8.
    T. J. Tewson, Nucl. Med. Biol., 16 (1989) 533.Google Scholar
  9. 9.
    G. L. Watkins, J. C. W. Richmond, L. L. Boles Ponto, R. D. Hichwa, J. Label. Comp. Radiopharm., 32 (1992) 131.Google Scholar
  10. 10.
    B. H. Mock, M. T. Vavrek, G. K. Mulholland, Nucl. Med. Biol., 23 (1966) 497.Google Scholar
  11. 11.
    J. W. Brodack, M. R. Kilbourn, M. J. Welch, J. A. Katzenellenbogen, Appl. Radiation Isotopes, 37 (1986) 217.Google Scholar

Copyright information

© Akadémiai Kiadó 1998

Authors and Affiliations

  • A. Bogni
    • 1
  • C. Pascali
    • 1
  • R. Iwata
    • 2
  • A. Cavalleri
    • 1
  • V. de Sanctis
    • 1
  • D. Decise
    • 1
  • G. Cucchetti
    • 1
  • F. Crippa
    • 1
  • C. Chiesa
    • 1
  • M. Schiavini
    • 1
  • M. Schiavini
    • 1
  • E. Bombardieri
    • 1
  1. 1.Department of Nuclear MedicineNational Cancer InstituteMilanItaly
  2. 2.CYRIC Tohoku UniversitySendaiJapan

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