Effect of disuse on the ultrastructure of the achilles tendon in rats

  • Yoshinao Nakagawa
  • Manabu Totsuka
  • Tomoaki Sato
  • Yoshiro Fukuda
  • Koichi Hirota
Article

Summary

We examined the influence exerted, through disuse of the hindlimb, on the collagen fibres of the achilles tendon in rats. With disuse the body mass decreased by 28%, and the mass of soleus muscle decreased by 20%. A decrease in the surface area and diameter was observed in the experimental group when compared to the control group. A histogram of the collagen fibres showed a decrease of the thick fibres in the experimental group. The maximum surface area of collagen fibres in the experimental group was seen to be only 43% of that of the control group. These results showed a decrease in the thickness of the collagen fibres of the achilles tendon through disuse. This seemed to suggest that resistance to tension is decreased by disuse.

Key words

Collagen fibre Achilles tendon Disuse Atrophy Ultrastructure 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Akeson WH (1961) An experimental study of joint stiffness. J Bone Joint Surg [Am] 43:1022–1034PubMedGoogle Scholar
  2. Desplanches D, Mayet MH, Sempore B, Flandrois R (1987) Structural and functional responses to prolonged hindlimb suspension in rat muscles. J Appl Physiol 63:558–563PubMedGoogle Scholar
  3. Flynn DE, Max SR (1985) Effect of suspension hypokinesia/hypodynamia on rat skeletal muscle. Aviat Space Environ Med 56:1065–1069PubMedGoogle Scholar
  4. Globus RK, Bikle DD, Morey-Holton E (1984) Effects of simulated weightlessness on bone mineral metabolism. Endocrinology 114:2264–2270PubMedGoogle Scholar
  5. Hauschka ED, Roy RR, Edgerton VR (1987) Size and metabolic properties of single muscle fibers in rat soleus after hindlimb suspension. J Appl Physiol 62:2338–2347PubMedGoogle Scholar
  6. Laros GS, Tipton CM, Cooper RR (1971) Influence of physical activity on ligament insertions in the knee of dogs. J Bone Joint Surgy [Am] 53:275–286Google Scholar
  7. Morey ER (1979) Spaceflight and bone turnover: correlation with a new rat model of weightlessness. BioScience 29:168–172Google Scholar
  8. Musacchia XJ, Steffen JM, Deavers DR (1983) Rat hindlimb muscle responses to suspension hypokinesia/hypodynamia. Aviat Space Environ Med 54:1015–1020PubMedGoogle Scholar
  9. Nakagawa Y, Sato T, Fukuda Y, Hirota K (1988) Effect of aerobic and anaerobic training on collagen fiber of tendon in rats. Jpn J Phys Fitness Sports Med 37:100–108Google Scholar
  10. Noyes FR (1977) Functional properties of knee ligaments and alterations induced by immobilization. Clin Orthop 123:210–242PubMedGoogle Scholar
  11. Noyes FR, Torvic PJ, Hyde WB, Delucas JL (1974) Biomechanics of ligament failure. J Bone Joint Surg [Am] 56A:1406–1418Google Scholar
  12. Rothman RH, Slogoff S (1967) The effect of immobilization on vascular bed of tendon. Surg Gynecol Obstet 124:1064–1066PubMedGoogle Scholar
  13. Steffen JM, Deavers DR, Musacchia XJ (1980) Increased excretion of water, urea, Na+ and K during head-down-tilt hypokinesia: a question of diet or antiorthostrasis. Physiologist 23:84Google Scholar
  14. Thomason DB, Herrick RE, Baldwin KM (1987) Activity influences on soleus muscle myosin during rodent hindlimb suspension. J Appl Physiol 63:138–144PubMedGoogle Scholar
  15. Tipton CM, Schild RJ, Tomanek RJ (1967) Influence of knee ligaments in rats. Am J Physiol 212:783–787PubMedGoogle Scholar
  16. Tipton CM, James SL, Mergner W, Tcheng TK (1970) Influence of exercise on strength of medical collateral knee ligament of dogs. Am J Physiol 218:894–902PubMedGoogle Scholar
  17. Tipton CM, Tcheng T, Mergner W (1971) Ligamentous strength measurements from hypophysectomized rats. Am J Physiol 221:1144–1150PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Yoshinao Nakagawa
    • 1
  • Manabu Totsuka
    • 2
  • Tomoaki Sato
    • 2
  • Yoshiro Fukuda
    • 3
  • Koichi Hirota
    • 2
  1. 1.Department of Sports SciencesOtaru University of CommerceOtaru-shiJapan
  2. 2.Department of Physical FitnessNippon College of Physical EducationTokyoJapan
  3. 3.Department of Pathology, School of MedicineJuntendo UniversityTokyoJapan

Personalised recommendations