Effect of dipyridamole on retinal embolism associated with cardiopulmonary bypass surgery in the dog

  • Isla M. Williams
  • Sue Farmer
  • Jeanette Fixon


In previous studies white retinal emboli have been observed during open heart surgery in patients who postoperatively developed neurological complications and in patients who failed to survive (Williams, 1973). In the present study similar white retinal emboli were experimentally produced in dogs undergoing total cardiopulmonary bypass and were shown to comprise blood platelets. Trypsin digest flat preparations of the retina showed multiple capillary occlusions, some having characteristics of denatured cellular material and fat, others resembling silicone grease in vessels. The incidence of experimentally produced emboli comprising blood platelets and other cellular material was significantly reduced by adding dipyridamole (Persantin-Boehringer Ingelheim) a substance which impairs aggregation and adhesiveness of platelets, to the perfusate.


Retina Trypsin Cardiopulmonary Bypass Grease Dipyridamole 
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In früheren Veröffentlichungen wurden weiße Emboli der Netzhautgefäße bei offenen Herzoperationen beobachtet, bei Patienten, die neurologische Komplikationen zeigten oder solchen, die den Eingriff nicht überlebten (Williams, 1973). In der vorliegenden Veröffentlichung wird über ähnliche weiße Retinaemboli bei Hunden berichtet, deren Kreislauf ganz über eine Herz-Lungen-Maschine geleitet wurde. Es zeigte sich, daß diese Emboli aus Thrombocyten bestanden. Trypsinbehandelte Flachpräparationen der Retina wiesen multiple capilläre Verschlüsse auf, von denen einige durch denaturiertes Zellmaterial und Fett charakterisiert waren, während andere aussahen, als sei Silikonfett in den Blutgefäßen. Das Auftreten von experimentell ausgelösten Emboli aus Thrombocyten und anderen Zellmaterialien war signifikant seltener, wenn dem Kreislaufsystem Dipyridamol (Persantin®-Boehringer/Ingelheim) zugefügt wurde. Diese Substanz wirkt der Aggregation und Verklebung der Thrombocyten entgegen.


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Isla M. Williams
    • 1
  • Sue Farmer
    • 1
  • Jeanette Fixon
    • 1
  1. 1.Monash Medical School Alfred HospitalMonash University Department of MedicineMelbourneAustralia

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