Diabetologia

, Volume 38, Issue 1, pp 125–125 | Cite as

Is liver type pyruvate kinase present in the normal pancreatic islet?

  • M. J. MacDonald
Letters to the Editors

Keywords

Public Health Internal Medicine Pyruvate Human Physiology Metabolic Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. 1.
    Marie S, D-G, M-J, Miquerol L, Kahn A, Iynedjian PB (1993) The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic b-cell type. J Biol Chem 268: 23881–23890PubMedGoogle Scholar
  2. 2.
    MacDonald MJ, Kowluru A (1985) Evidence of calcium enhanced phosphorylation of pyruvate kinase by pancreatic islets. Mol Cell Biochem 68: 107–114PubMedGoogle Scholar
  3. 3.
    MacDonald MJ, Chang C-M (1985) Pancreatic islets contain the M2 isoenzyme of pyruvate kinase. Its phosphorylation has no effect on enzyme activity. Mol Cell Biochem 68: 115–120PubMedGoogle Scholar
  4. 4.
    Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB (1992) Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130: 167–178CrossRefPubMedGoogle Scholar
  5. 5.
    MacDonald MJ, Chang C-M (1985) Do pancreatic islets contain significant amounts of phosphoenolpyruvate carboxykinase or ferroactivator activity? Diabetes 34: 246–250PubMedGoogle Scholar
  6. 6.
    MacDonald MJ, McKenzie DI, Walker TM, Kaysen JH (1992) Lack of glyconeogenesis in pancreatic islets: expression of gluconeogenic enzyme genes in islets. Horm Metab Res 24: 158–160PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • M. J. MacDonald
    • 1
  1. 1.University of Wisconsin Medical School, University AvenueMadisonUSA

Personalised recommendations