Annals of Biomedical Engineering

, Volume 17, Issue 5, pp 475–482 | Cite as

Simultaneous measurement of stroke volume by impedance cardiography and nuclear ventriculography: Comparisons at rest and exercise

  • Michael F. Wilson
  • Bong Hee Sung
  • Gwendolyn A. Pincomb
  • William R. Lovallo


We have conducted four major impedance cardiography (ZCG) studies to provide data on validity, reproducibility, and sensitivity of response to interventions. The reference technique was quantitative nuclear ventriculography (NVG). Subjects were healthy young men in situations where minimally invasive and unobtrusive techniques were preferred. Interventions used included caffeine ingestion and exercise. Validity of ZCG estimates of stroke volume index (SVI, ml/m2) was tested in 35 men at rest. SVI was 49±9 by ZCG and 46±7 by NVG (r=0.82). Measurements of SVI during bicycle exercise showed no overall difference by the two methods (F=0.26, P=NS). Vascular resistance index (mean BP/CI) increased comparably by both techniques (+9.6% by ZCG and +9.7% by NVG) following caffeine (3.3 mg/kg). The reproducibility of ZCG was demonstrated in the day-to-day consistency of caffeine's effect on vascular resistance in 3 other studies (+11.9%, 12%, and 8.9%). Reliability across and within days was shown by repeated tests in the same subjects (SVI, r's=.96, .92). Conclusion: Impedance cardiography was shown to be a useful noninvasive technique for evaluation of cardiodynamics in biomedical research since it was highly reproducible and yielded equivalent results of relative changes produced by pharmacological and physical challenge. In addition, there was good agreement with NVG in absolute values for grouped data.


Impedance cardiography Nuclear ventriculography Stroke volume 


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Copyright information

© Pergamon Press plc 1989

Authors and Affiliations

  • Michael F. Wilson
    • 1
    • 2
  • Bong Hee Sung
    • 2
    • 3
  • Gwendolyn A. Pincomb
    • 1
    • 4
  • William R. Lovallo
    • 1
    • 4
  1. 1.Research Service, VA Medical CenterUniversity of Oklahoma Health Sciences CenterOklahoma City
  2. 2.Department of MedicineUniversity of Oklahoma Health Sciences CenterOklahoma City
  3. 3.Departments of Psychiatry and Behavioral SciencesUniversity of Oklahoma Health Sciences CenterOklahoma City
  4. 4.College of PharmacyUniversity of Oklahoma Health Sciences CenterOklahoma City

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