The role of dopaminergic mechanisms of the brain in various models of anxious states
In tests of “illuminated area” and the “threatening situation” avoidance by rats, apomorphine and phenamine, administered intraperitoneally, attenuate the state of alarm. A similar effect is observed when sulpiride, a selective blocker of D2-receptors of dopamine, and of picrotoxin, a GABA antagonist, are administered. Sulpiride effectively counteracts the anxiolytic effects of all of the dopaminomimetics investigated and of picrotoxin. Haloperidol, a nonselective blocker of the D1-and D2-receptors of dopamine removes the anxiolytic effect of apomorphine, phenamine, and picrotoxin. The microinjection into the ventral region of the midbrain tegmentum of dopamine, or of sulpiride into the nucleus accumbens of the septum, attenuates the state of alarm formed by aversive influences of various biological modalities. By contrast, sulpiride, introduced locally into the tegmentum, or chemical stimulation of the nucleus accumbens of the septum by dopamine, intensifies the state of alarm in the “illuminated area” avoidance test. The participation of dopaminergic mechanisms of the mesolimbic system of the brain in anxiety of various aversive causations is discussed.
Unable to display preview. Download preview PDF.
- 1.Ya. Buresh, M. Petran', and I. Zakhar, Electrophysiological Research Methods [Russian translation], Moscow (1962).Google Scholar
- 2.A. N. Talalaenko, G. K. Krivobok, A. V. Chenikov, et al., “The monoamine-and acidergic mechanisms of the raphé nuclei in various tests of anxiety”, Fiziol. Zhurn. SSSR, 77, No. 2, 119–123 (1991).Google Scholar
- 4.B. S. Bunney, G. K. Aghajanjan, and R. H. Roth, “Comparison of effect of L-DOPA, amphetamine and apomorphine on firing rate of rat dopaminergic neurons”, Nature, 245, No. 4865, 123–125 (1973).Google Scholar
- 5.M. H. Chauchrd, “Psychopharmacology du dogmatil”, Sem. Hop. Paris, 61, No. 30, 2186–2190 (1985).Google Scholar
- 6.J. Glowinski, J. P. Tassin, and M. H. Thierry, “The mesocorticoprefrontal dopaminergic neurons”, Trends Neurosci. 7: No. 11, 415–418 (1984).Google Scholar
- 11.R. Redolat, P. Brain, and V. Simon, “Investigation of the anxiolytic properties of the neuroleptic sulpiride using the agonistic responses of female mice,” Aggress. Behav., 15, No. 1, 109 (1989).Google Scholar
- 12.W. Reinmann, A. Zumstein, and G. Hertling, “Inhibition of dopamine release from rabbit nucleus caudatus by apomorphine and bromcriptine,” Naunyn Schmiedeberg's Arch. Pharmacol., 302, Suppl. S, 50 (1978).Google Scholar
- 13.G. S. Roberts and A. H. Roberts, “D1 and D2 dopamine agonists synergism. Separate sites of action,” Trends Pharmacol. Sci., 8, 295–299 (1987).Google Scholar
- 19.P. Westerling, S. Lindgren and U. Huglund, “Dopamine mediated behavior and GABA influence,” Pharmacol. Biochem. and Behav., 31, No. 3, 593–596 (1988).Google Scholar