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Journal of Gastroenterology

, Volume 29, Issue 4, pp 486–494 | Cite as

Direct dissolution of gallstones with methyl tert-butyl ether (MTBE) via endoscopic transpapillary catheterization in the gallbladder (ETCG)

  • Naohito Uchida
  • Toshiaki Nakatsu
  • Shuko Hirabayashi
  • Atsushi Minami
  • Hiroki Fukuma
  • Toru Ezaki
  • Syed Ahmed Morshed
  • Chiaki Fuke
  • Kiyoshi Ameno
  • Iwao Ijiri
  • Mikio Nishioka
Article

Abstract

In a pilot study of direct dissolution therapy of gallstones with methyl tert-butyl ether (MTBE), endoscopic transpapillary catheterization in the gallbladder (ETCG) was performed. Complete dissolution was seen in 8 out of 12 (66%) patients and partial dissolution was seen in 2 (16%) patients. In one of the 8 complete dissolution patients, combined extracorporeal shock wave lithotripsy (ESWL) and dissolution therapy was carried out successfully. These 8 patients were followed up for 12–20 months with regular ultrasonography. During this period, 1 patient underwent laparoscopic cholecystectomy due to stone recurrence. Thickening of the gallbladder wall was seen in 2 patients, but there were no other complications. Using Tsuchiya's classification based on ultrasound, complete dissolution was seen in type Ia stones. This pilot study suggests that the direct dissolution of gallstones with MTBE via ETCG might be a useful and safe non-invasive treatment in patients with cholesterol stones in preserved gallbladders.

Key words

ETCG gallstone dissolution therapy MTBE ESWL 

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Naohito Uchida
    • 1
  • Toshiaki Nakatsu
    • 1
  • Shuko Hirabayashi
    • 1
  • Atsushi Minami
    • 1
  • Hiroki Fukuma
    • 1
  • Toru Ezaki
    • 1
  • Syed Ahmed Morshed
    • 1
  • Chiaki Fuke
    • 2
  • Kiyoshi Ameno
    • 2
  • Iwao Ijiri
    • 2
  • Mikio Nishioka
    • 1
  1. 1.Third Department of Internal MedicineKagawa Medical SchoolKagawaJapan
  2. 2.Forensic MedicineKagawa Medical SchoolKagawaJapan

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