Journal of Gastroenterology

, Volume 29, Issue 4, pp 403–405

Detection of serum IgG antibody againstHelicobacter pylori from childhood in a Japanese population

  • Norio Matsukura
  • Masahiko Onda
  • Akira Tokunaga
  • Tadashi Teramoto
  • Itsuo Fujita
  • Takeshi Okuda
  • Kiyohiko Yamashita
Article

Abstract

Epidemiological evidence has shown that seropositivity forHelicobacter pylori in the stomach is positively correlated with the incidence of gastric cancer. In this study, we investigated serum IgG antibody againstH. pylori in asymptomatic Japanese subjects by an enzyme-linked immunoassay (ELISA) method (Serion, Wuerzburg, Germany). We noted two characteristics: (1) Seropositivity was seen in 41% of individuals aged less than 1 year, and in 9% of those aged 1–2 years, indicating the possibility that IgG antibody in infancy is derived from the mother. (2) Seropositivity was seen in 35% of individuals aged 15–19 years compared to 70% in those aged 20–24 years, indicating the spread ofH. pylori infection with age.

Key words

Helicobacter pylori IgG antibody childhood Japanese 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Warren JR, Marshall BJ. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983;1:1273–1275.Google Scholar
  2. 2.
    Morris A, Nicholson G. Ingestion ofCampylobacter pyloridis causes gastritis and raises fasting gastric pH. Am J Gastroenterol 1987;82:192–199.PubMedGoogle Scholar
  3. 3.
    Rauws EAJ, Langenberg W, Houthoff HJ, et al.Campylobacter pyloridis-associated chronic active antral gastritis: A prospective study of its prevalence and the effects of antibacterial and antiulcer treatment. Gastroenterology 1988;94:33–40.PubMedGoogle Scholar
  4. 4.
    Nomura A, Stemmermann GN, Chyou P-K, et al.Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 1991;325:1132–1136.PubMedGoogle Scholar
  5. 5.
    Parsonnet J, Friedman GD, Vandersteen DP, et al.Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991;325:1127–1131.PubMedGoogle Scholar
  6. 6.
    Forman D, Newell DG, Fullerton F, et al. Association between infection withHelicobacter pylori and risk of gastric cancer: Evidence from a prospective investigation. BMJ 1991;302:1302–1305.PubMedGoogle Scholar
  7. 7.
    The Eurogast Study Group. An international association betweenHelicobacter pylori infection and gastric cancer. Lancet 1993;341:1359–1362.Google Scholar
  8. 8.
    Correa P. A human model of gastric carcinogenesis. Cancer Res 1988;48:3554–3560.PubMedGoogle Scholar
  9. 9.
    Kato I, Tominaga S, Ito Y, et al. A prospective study of atrophic gastritis and stomach cancer risk. Jpn J Cancer Res 1992;83:1137–1142.PubMedGoogle Scholar
  10. 10.
    Marshall B.Campylobacter pyloridis and gastritis. J Infect Dis 1986;153:650–657.PubMedGoogle Scholar
  11. 11.
    Dixon MF.Campylobacter pylori and chronic gastritis.Campylobacter pylori and gastroduodenal disease. Oxford: Blackwell Scientific Publications. 1989;106–116.Google Scholar
  12. 12.
    Wyatt JI, Dixon MF. Chronic gastritis—a pathogenetic approach. J Pathol 1988;154:113–124.CrossRefPubMedGoogle Scholar
  13. 13.
    Imai T, Kubo T, Watanabe H. Chronic gastritis in Japanese with reference to high incidence of gastric carcinoma. JNCI 1971;47:179–195.PubMedGoogle Scholar
  14. 14.
    Asaka M, Kimura T, Kudo M, et al. Relationship ofHelicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology 1992;102:760–766.PubMedGoogle Scholar
  15. 15.
    Inouye H, Yamamoto I, Tanida N, et al.Campylobacter pylori in Japan: Bacteriological features and prevalence in healthy subjects and patients with gastroduodenal disorders. Gastroenterol Jpn 1989;24:494–504.PubMedGoogle Scholar
  16. 16.
    Marshall B, Goodwin CS, Warren JR, et al. Prospective double-blind trial of duodenal ulcer relapse after eradication ofCampylobacter pylori. Lancet 1988;2:1437–1442.PubMedGoogle Scholar
  17. 17.
    McKinlay AW, Upadhyay R, Gemmell CG, Russell RI.Helicobacter pylori: Bridging the credibility gap. Gut 1990;31: 940–945.PubMedGoogle Scholar
  18. 18.
    Evans DJ, Evans DG, Graham DY, et al. A sensitive and specific serologic test for detection ofCampylobacter pylori infection. Gastroenterology 1989;96:1004–1008.PubMedGoogle Scholar
  19. 19.
    Graham DY, Malaty HM, Evans DG, et al. Epidemiology ofHelicobacter pylori in an asymptomatic population in the United States: Effect of age, race, and socioeconomic status. Gastroenterology 1991;100:1495–1501.PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Norio Matsukura
    • 1
  • Masahiko Onda
    • 1
  • Akira Tokunaga
    • 1
  • Tadashi Teramoto
    • 1
  • Itsuo Fujita
    • 1
  • Takeshi Okuda
    • 1
  • Kiyohiko Yamashita
    • 1
  1. 1.First Department of SurgeryNippon Medical SchoolTokyoJapan

Personalised recommendations