Evaluation of omental implantation for perforated gastric ulcer therapy: Findings in a rat model
- 42 Downloads
Omental implantation, a surgical procedure in which a perforated gastric or duodenal ulcer is repaired by drawing and implanting a portion of the omentum into the digestive tract, accelerates ulcer healing and inhibits ulcer recurrence. However, the mechanisms underlying these beneficial effects are largely unknown. To clarify these mechanisms, we investigated ulcer healing in two groups of rats in which acetic acid-induced gastric ulcers were perforated. Omental implantation was used for repair in one group and simple suturing was employed in the other group. Greater antiinflammatory and angiogenic activity and accelerated collagen synthesis were seen in the omental implantation group. Basic fibroblast growth factor (bFGF)-mediated angiogenesis was noted in this group, as well as transforming growth factor-β1 (TGF-β1) activity within and around the omentum, resulting in abundant collagen production. It was confirmed that omental implantation accelerated ulcer healing and inhibited ulcer recurrence, and the presence of bFGF and TGF-β1 played a significant role in both these phenomena.
Key wordsomental implantation omentum perforated gastro-duodenal ulcer ulcer recurrence growth factor
Unable to display preview. Download preview PDF.
- 1.Boey J, Wong J. Perforated duodenal ulcer. World J Surg 1984;11:319–324.Google Scholar
- 2.Skovgaad S. Late results of perforated duodenal ulcer treated by simple suture. World J Surg 1977;1:521–526.Google Scholar
- 3.Tsuchiya Y, Matsubayashi F, Hirai M, et al. Omental implantation on gastroduodenal perforations. Chir Gastroenterol (Surg Gastroenterol) 1979;13:235–243.Google Scholar
- 4.Hirai M. A study of omental implantation on benign gastroduodenal perforations (in Japanese with English abstract). Nichiidaishi (J Nippon Med School) 1981;48:623–631.Google Scholar
- 6.Monden T, Morimoto H, Nakanishi H, et al. A comparative immunohistochemical study of p53 and heat shock protein expression in microwave-fixed, paraffin-embedded sections of colorectal tumors. Acta Histochem Cytochem 1992;25:583–590.Google Scholar
- 9.Fukawa K, Kawano O, Misaki N, et al. Experimental studies on gastric ulcer (6). Endoscopic evaluation of healing processes of acetic acid ulcer in rats (2): Healing, recurrence and relapse of ulcer (in Japanese with English abstract). Nihon Yakurigakkai Zasshi (Fol Pharmacol Jap) 1981;83:69–77.Google Scholar