Neuroscience and Behavioral Physiology

, Volume 25, Issue 2, pp 142–149 | Cite as

Electroencephalographic correlates of neurological disturbances at remote periods of the effect of ionizing radiation (Sequelae of the Chernobyl' NPP accident)

  • L. A. Zhavoronkova
  • N. B. Kholodova
  • G. A. Zubovskii
  • Yu. N. Smirnov
  • Yu. M. Koptelov
  • N. I. Ryzhov
Article

Abstract

The psychoneurological status of 40 participants (all men aged 25–45 years, official dose 15–51 rem) in the liquidation of the consequences of the accident at the Chernobyl Nuclear Power Plant in 1986–1987 was investigated; EEG mapping and three-dimensional localization of the sources of epileptic activity as compared with the data of healthy individuals (20 individuals) was carried out. Vegetative—vascular symptomatology was identified in the neurological status of all the patients; disseminated organic neurological symptomatology and endocrine disturbances were additionally identified in some of the patients. There were paroxysmal attacks periodically in the overwhelming majority (68%) of the patients; this correlated with the presence in the EEG of epileptic forms of activity. The patients were divided into two groups on the basis of the character of the EEG. Patients in whom slow alpha waves and waves of the theta range with a “focus” in the central-frontal regions of the cortex were recorded were included in group I (25 individuals). Analysis of the localization of the sources of epileptic activity revealed placement at the midline level in them with marked compactness and displacement of the focus to the right hemisphere. In the patients of group II (15 individuals), slow waves of frontal localization and diffuse beta waves predominated in the EEG in the presence of a reduction in the level of biopotentials. The localization of equivalents of epileptic activity was more diffuse in character and was at the basal level, with a greater representation of the sources of epileptic activity in the left hemisphere. The results presented, as compared with previously obtained data of x-ray and single photon emission computed tomography examination, make it possible to hypothesize an organic lesion in these patients of various divisions of the brain, both of cortical and midline localization, with involvement in the pathological process of the limbicoreticular complex, with maximal disturbances of the hypothalamohypophyseal system that associated with adaptive-compensatory processes of the CNS.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    G. N. Boldyreva, The Intercenter Relationships in the Cerebral Cortex of Man in the Norm and with a Focal Lesion of the Diencephalic Structures. Diss. ... Doct. Biol. Sciences, NVND i NF AN SSSR, Moscow (1978).Google Scholar
  2. 2.
    O. M. Grindel', The Human Electroencephalogram in Craniocerebral Trauma [in Russian], Nauka, Moscow (1988).Google Scholar
  3. 3.
    Z. L. Gurnitskaya and A. I. Isroilov, “Contemporary notions of the effect of small doses of radiation,” Zdravookhr. Kirgiziya, No. 5, 60 (1989).Google Scholar
  4. 4.
    B. I. Davydov, B. I. Ushakov, and V. P. Fedorov, Radiation Damage of the Brain [in Russian], Énergoizdat, Moscow (1991).Google Scholar
  5. 5.
    T. A. Dobrokhotova and N. N. Bragina, Functional Asymmetry and the Psychopathology of Focal Lesions of the Brain [in Russian], Meditsina, Moscow (1977).Google Scholar
  6. 6.
    L. A. Zhavaronkova, “The features of the dynamics of interhemispheric relationships of the EEG during the restoration of human nervous and mental activity,”Zhurn. Vyssh. Nerv. Deyat.,40, No. 2, 238 (1990).Google Scholar
  7. 7.
    Yu. M. Koptelov and V. V. Gnezditskii, “The analysis of scalp potential fields and the three-dimensional localization of equivalent sources of epileptic activity of the human brain,” Zhurn. Vyssh. Nerv. Deyat.,80, No. 6, 11 (1989).Google Scholar
  8. 8.
    G. D. Kuznetsova, N. L. Fedorova, and N. B. Kholodova, “The influence of ionizing radiation on the functional state of the nervous system of the monkey,” in: Summ. Reports of Conf.: Psychosocial, Psychological, and Psychoneurological Aspects of the Sequelae of the Accident at the Chernobyl' NPP, Kiev, 27–29 Sept., 1992.Google Scholar
  9. 9.
    M. N. Livanov, Some Problems of the Effect of Ionizing Radiation [in Russian], Meditsina, Moscow (1962).Google Scholar
  10. 10.
    A. I. Nyagu, A. G. Noshchenko, and K. N. Loganovskii, “The influence of factors of the emergency situation at the Chernobyl' NPP on the functional state of afferent systems,” in: Summ. Reports of Conf.: Psychosocial, Psychological, and Psychoneurological Aspects of the Sequelae of the Accident at the Chernobyl' NPP, Kiev, 27–29 Sept., 1992.Google Scholar
  11. 11.
    A. G. Noshchenko and K. N. Loganovskii, “Electrophysiological manifestations of the functional state of the brain in workers liquidating the accident at the Chernobyl' NPP with a syndrome of vegetative dysfunction,” in: Summ. of a Republic Conf., Minsk, 1991.Google Scholar
  12. 12.
    Radiation Medicine [in Russian], Gosatomizdat, Moscow (1963).Google Scholar
  13. 13.
    V. S. Rusinov, O. M. Grindel', G. N. Boldyreva, and E. M. Vakar, Brain Biopotentials of Man. Mathematical Analysis [in Russian], Meditsina, Moscow (1987).Google Scholar
  14. 14.
    G. V. Selitskii, The Neuroendocrine Regulation of Epileptogenesis, Abstract Diss. ... Doct. Med. Sciences, In-t VND i NF AN SSSR, Moscow (1991).Google Scholar
  15. 15.
    A. K. Cheban, “The neuroendocrine system of adaptation in the presence of the prolonged effect of factors of the 30-kilometer zone on the human organism,” in: Summ. Reports of Conf.: Psychosocial, Psychological, and Psychoneurological Aspects of the Sequelae of the Accident at the Chernobyl' NPP, Kiev, 27–29 Sept., 1992.Google Scholar
  16. 16.
    N. B. Kholodova, É. V. Krivenko, G. A. Zubovskii, and M. V. Sheikh, “Changes in the brain in individuals participating in the liquidation of the sequelae of the accident at the Chernobyl' NPP in 1986–1987, based on clinical and x-ray computed tomography data,” in: Summ. Reports of Conf.: Psychosocial, Psychological, and Psychoneurological Aspects of the Sequelae of the Accident at the Chernobyl' NPP, Kiev, 27–29 Sept., 1992.Google Scholar
  17. 17.
    K. F. Baverstock and J. W. Stather, Low Dose Radiations: Biological Bases of Risk Assessment, London (1989).Google Scholar
  18. 18.
    D. L. Colins, A. Baum, and J. E. Singer, “Coping with chronic stress at Three Mile Island: Physiological and Biochemical Evidence,” Health Psychol., 149 (1983).Google Scholar
  19. 19.
    W. M. Lomer and R. H. Taylor, “Epidemiology assessment of cancer risk at low doses and dose rates,” in: Radiat. Protect. Nucl. Energy, Vienna (1988), p. 121.Google Scholar
  20. 20.
    B. Modan, “Cancer and leukemia risk after low level radiation,” Med. Oncol. Tumor Pharamacother.,4, 151 (1987).Google Scholar
  21. 21.
    E. E. Pochin, “Meeting report. Health effects of low dose ionizing radiation — recent advance and their implications,” Int. J. Radiol. Biol.,52, 659 (1987).Google Scholar
  22. 22.
    M. A. Schaffer and A. Baum, “Adrenal cortical response to stress at Three Mile Island,” Psychosom. Med.,46, 227 (1984).Google Scholar
  23. 23.
    A. Upton, “Cancerogenic effects of low-level ionizing radiation,” J. Nat. Cancer Inst.,82, 448 (1990).PubMedGoogle Scholar
  24. 24.
    L. Zhavaronkova, N. Kholodova, G. Zubovskij, et al., “EEG and metabolic mapping data correlate with neurological disturbances in patients from Chernobyl,” in: 1 Deutsches EEG/EP Mapping Meeting, Giessen, 11–12 Sept. 1992, Brain Topography, Vol. 5, (1993), p. 296Google Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • L. A. Zhavoronkova
  • N. B. Kholodova
  • G. A. Zubovskii
  • Yu. N. Smirnov
  • Yu. M. Koptelov
  • N. I. Ryzhov

There are no affiliations available

Personalised recommendations